Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nicotinic receptors in the brain: Links between molecular biology and behavior
Autore:
Picciotto, MR; Caldarone, BJ; King, SL; Zachariou, V;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 451 - 465
SICI:
0893-133X(200005)22:5<451:NRITBL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; EXCITATORY SYNAPTIC TRANSMISSION; LOCOMOTOR STIMULANT ACTION; INDUCED DOPAMINE RELEASE; ACOUSTIC STARTLE REFLEX; SUBUNIT MESSENGER-RNAS; CENTRAL-NERVOUS-SYSTEM; ACETYLCHOLINE-RECEPTORS; LATENT INHIBITION; NUCLEUS-ACCUMBENS;
Keywords:
nicotine; knock out mice; reinforcement; learning;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Picciotto, MR Yale Univ, Sch Med, Dept Psychiat, 34 Pk St,3rd Floor Res, New Haven, CT 06508 USA Yale Univ 34 Pk St,3rd Floor Res New Haven CT USA 06508 USA
Citazione:
M.R. Picciotto et al., "Nicotinic receptors in the brain: Links between molecular biology and behavior", NEUROPSYCH, 22(5), 2000, pp. 451-465

Abstract

Molecular cloning has elucidated the sequence of a family of acetylcholinereceptor subunits that are activated by nicotine. Subsequent studies on the localization of individual subunits and the physiological properties of nicotinic subunit combinations in vitro, have led to identification of subunit compositions of nicotinic receptors that may function in vivo, as the native receptor. A particular challenge for the field has been to use these molecular data to determine which individual nicotinic receptor subtype is responsible for mediating each of the behavioral effects of nicotine. Human and animal studies hav shown that nicotine is reinforcing and likely responsible for the addictive properties of tobacco. In addition, nicotine has been shown to have effects on locomotion, cognition, affect, and pain sensitivity. Recent studies combining the techniques of molecular biology, pharmacology, electrophysiology, and behavioral analysis to analyze knock out micethat lack individual subunits of the nicotinic acetylcholine receptor, have helped identify the role of specific nicotinic subunits in some of these complex behaviors. These studies could ultimately be useful in designing specific nicotinic receptor agonists and antagonists that may have uses in the clinic. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:44:11