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Titolo:
Line bisection judgments implicate right parietal cortex and cerebellum asassessed by fMRI
Autore:
Fink, GR; Marshall, JC; Shah, NJ; Weiss, PH; Halligan, PW; Grosse-Ruyken, M; Ziemons, K; Zilles, K; Freund, HJ;
Indirizzi:
Univ Dusseldorf, Neurol Klin, D-40001 Dusseldorf, Germany Univ DusseldorfDusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany Univ Dusseldorf, C&O Vogt Hirnforschungsinst, D-40001 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40001 , D-40001 Dusseldorf, Germany KFA Julich GmbH, Forschungszentrum, Inst Med, Julich, Germany KFA Julich GmbH Julich Germany chungszentrum, Inst Med, Julich, Germany Radcliffe Infirm, Univ Dept Clin Neurol, Neuropsychol Unit, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE ol Unit, Oxford OX2 6HE, England Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 54, anno: 2000,
pagine: 1324 - 1331
SICI:
0028-3878(20000328)54:6<1324:LBJIRP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-ATTENTION; VISUOSPATIAL NEGLECT; DISTORTION; BRAIN; TASK;
Keywords:
visuospatial neglect; landmark task; temporoparietal cortex; cerebellum; fMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fink, GR Univ Dusseldorf, Neurol Klin, Postfach 10 10 07, D-40001 Dusseldorf, Germany Univ Dusseldorf Postfach 10 10 07 Dusseldorf Germany D-40001 any
Citazione:
G.R. Fink et al., "Line bisection judgments implicate right parietal cortex and cerebellum asassessed by fMRI", NEUROLOGY, 54(6), 2000, pp. 1324-1331

Abstract

Objective: To use functional MRI (fMRI) to determine which brain regions are implicated when normal volunteers judge whether pretransected horizontalLines are correctly bisected (the Landmark test). Background: Manual line bisection and a variant thereof involving perceptual judgments of pretransected lines (the Landmark test) are widely used to assess unilateral visuospatial neglect in patients with neurologic disease. Although unilateral (left) neglect most often results from lesions to right temporoparietal cortex,the normal functional anatomy of the Landmark test has not been convincingly demonstrated. Methods: fMRI was carried out in 12 healthy right-handed male volunteers who judged whether horizontal lines were correctly prebisected. In the control task, subjects detected whether the horizontal lines contained a transection mark irrespective of the position of that mark. Response was by two-choice key press: on half the trials, subjects used the right, and on half, the left hand. Statistical analysis of evoked blood oxygenation level-dependent responses, measured with echoplanar imaging, employed statistical parametric mapping. Results: Performing the Landmark task: showed neural activity (p < 0.05, corrected) in the right superior posterior andright inferior parietal lobe, early visual processing areas bilaterally, the cerebellar vermis, and the left cerebellar hemisphere. Only the latter area showed a significant interaction with hand used. Conclusions: The righthemispheric dominance observed in inferior parietal cortex is consistent with the results of lesion studies. Right superior parietal cortex, vermis, and left cerebellar hemisphere have not been implicated in neglect, but allappear to play a cognitive role in the Landmark task.

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Documento generato il 21/01/20 alle ore 07:04:07