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Titolo:
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
Autore:
Bale, TL; Contarino, AB; Smith, GW; Chan, R; Gold, LH; Sawchenko, PE; Koob, GF; Vale, WW; Lee, KF;
Indirizzi:
Salk Inst, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA Salk Inst La Jolla CA USA 92037 Labs Peptide Biol, La Jolla, CA 92037 USA Salk Inst, Neuronal Struct & Funct Lab, La Jolla, CA USA Salk Inst La Jolla CA USA Neuronal Struct & Funct Lab, La Jolla, CA USA Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA USA Scripps Res Inst La Jolla CA USA , Dept Neuropharmacol, La Jolla, CA USA
Titolo Testata:
NATURE GENETICS
fascicolo: 4, volume: 24, anno: 2000,
pagine: 410 - 414
SICI:
1061-4036(200004)24:4<410:MDFCHR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; CENTRAL NUCLEUS; ACTH-SECRETION; RAT-BRAIN; NEUROPEPTIDE; UROCORTIN; AMYGDALA; PARTICIPATION; HYPOTHALAMUS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KF Salk Inst, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA Salk Inst La Jolla CA USA 92037 tide Biol, La Jolla, CA 92037 USA
Citazione:
T.L. Bale et al., "Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress", NAT GENET, 24(4), 2000, pp. 410-414

Abstract

Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to stress, Crh releasedfrom the paraventricular nucleus (PVN) of the hypothalamus activates Crh receptors on anterior pituitary corticotropes, resulting in release of adrenocorticotropic hormone (Acth) into the bloodstream. Acth in turn activates Acth receptors in the adrenal cortex to increase synthesis and release of glucocorticoids(1). The receptors for Crh, Crhr1 and Crhr2, are found throughout the central nervous system and periphery. Crh has a higher affinity for Crhr1 than for Crhr2, and urocortin (Ucn); a Crh-related peptide, is thought to be the endogenous ligand for Crhr2 because it binds with almost 40-fold higher affinity than does Crh (ref. 2). Crhr1 and Crhr2 share approximately 71% amino acid sequence similarity and are distinct in their localization within the brain and peripheral tissues(3-6). We generated mice deficient for Crhr2 to determine the physiological role of this receptor. Crhr2-mutant mice are hypersensitive to stress and display increased anxiety-like behaviour. Mutant mice have normal basal feeding and weight gain, but decreased food intake following food deprivation. intravenous Ucn produces no effect on mean arterial pressure in the mutant mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:53:54