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Titolo:
Understanding the multiple functions of Nramp1
Autore:
Blackwell, JM; Searle, S; Goswami, T; Miller, EN;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge Inst Med Res,Welcome Trust Ctr Study Mo, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY Mo, Cambridge CB2 2XY, England
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 3, volume: 2, anno: 2000,
pagine: 317 - 321
SICI:
1286-4579(200003)2:3<317:UTMFON>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE PROTEIN GENE; NATURAL-RESISTANCE; MYCOBACTERIAL INFECTIONS; INTRACELLULAR PARASITES; SUSCEPTIBLE MICE; ENDOSOME FUSION; TASTE BEHAVIOR; CANDIDATE; IDENTIFICATION; ACTIVATION;
Keywords:
Nramp family; divalent cation transport; macrophage activation; infectious disease; autoimmunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Blackwell, JM Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Cambridge Inst Med Res,Welcome Trust Ctr Study Mo, Wellcome Trust MRC Bldg,Hills Rd, Cambridge CB2 2XY, England Univ Cambridge Wellcome Trust MRC Bldg,Hills Rd Cambridge England CB2 2XY
Citazione:
J.M. Blackwell et al., "Understanding the multiple functions of Nramp1", MICROBES IN, 2(3), 2000, pp. 317-321

Abstract

Nramp1 regulates macrophage activation in infectious and autoimmune diseases. Nramp2 controls anaemia. Both are divalent cation (Fe2+, Zn2+, and Mn2+) transporters; Nramp2 a symporter of H+ and metal ions, Nramp1 a H+/divalent cation antiporter. This provides a model for metal ion homeostasis in macrophages. Nramp2, localised to early endosomes, delivers extracellularly acquired divalent cations into the cytosol. Nramp1, localised to late endosomes/lysosomes, delivers divalent cations from the cytosol to phagolysosomes. Here, Fe2+ generates antimicrobial hydroxyl radicals via the Fenton reaction. Zn2+ and Mn2+ may also influence endosomal metalloprotease activity and phagolysosome fusion. The many cellular functions dependent on metal ionsas cofactors may explain the multiple pleiotropic effects of Nramp1, and its complex roles in infectious and autoimmune disease. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:00:26