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Titolo:
CR3: a general purpose adhesion-recognition receptor essential for innate immunity
Autore:
Ehlers, MRW;
Indirizzi:
BioNebraska Inc, Lincoln, NE 68524 USA BioNebraska Inc Lincoln NE USA 68524 oNebraska Inc, Lincoln, NE 68524 USA
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 3, volume: 2, anno: 2000,
pagine: 289 - 294
SICI:
1286-4579(200003)2:3<289:CAGPAR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT RECEPTOR-TYPE-3; I-DOMAIN; MYCOBACTERIUM-TUBERCULOSIS; DEPENDENT PHAGOCYTOSIS; LEUKOCYTE INTEGRINS; RESPIRATORY BURST; HUMAN NEUTROPHILS; LECTIN SITE; CD11B/CD18; BINDING;
Keywords:
integrin; phagocytosis; signaling; complement; leukocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ehlers, MRW BioNebraska Inc, 3820 NW 46th St, Lincoln, NE 68524 USA BioNebraska Inc 3820 NW 46th St Lincoln NE USA 68524 68524 USA
Citazione:
M.R.W. Ehlers, "CR3: a general purpose adhesion-recognition receptor essential for innate immunity", MICROBES IN, 2(3), 2000, pp. 289-294

Abstract

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:13:49