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Titolo:
Surface ectoderm is necessary for the morphogenesis of somites
Autore:
Correia, KM; Conlon, RA;
Indirizzi:
Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Hosp Cleveland, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 eland, Cleveland, OH 44106 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 91, anno: 2000,
pagine: 19 - 30
SICI:
0925-4773(20000301)91:1-2<19:SEINFT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESOMITIC MESODERM; PARAXIAL MESODERM; DELTA-HOMOLOG; NEURAL-TUBE; SOMITOMERIC ORGANIZATION; EXPRESSION PATTERN; SONIC HEDGEHOG; MOUSE EMBRYOS; GENE; SEGMENTATION;
Keywords:
somites; segmentation; epithelialization; inductive signaling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Correia, KM Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 OH 44106 USA
Citazione:
K.M. Correia e R.A. Conlon, "Surface ectoderm is necessary for the morphogenesis of somites", MECH DEVEL, 91(1-2), 2000, pp. 19-30

Abstract

The paraxial mesoderm of the neck and trunk of mouse embryos undergoes extensive morphogenesis in forming somites. Paraxial mesoderm is divided into segments, it elongates along its anterior posterior axis, and its cells organize into epithelia. Experiments were performed to determine if these processes are autonomous to the mesoderm that gives rise to the somites. Presomitic mesoderm at the tailbud stage was cultured in the presence and absenceof its adjacent tissues. Somite segmentation occurred in the absence of neural tube, notochord, gut and surface ectoderm. and occurred in posterior fragments in the absence of anterior presomitic mesoderm. Mesodermal expression of DllI and NotchI, genes with roles in segmentation, was largely independent of other tissues, consistent with autonomous segmentation. However, surface ectoderm was found to be necessary for elongation of the mesoderm along the anterior-posterior axis and for somite epithelialization. To determine if there is specificity in the interaction between ectoderm and mesoderm, ectoderm from different sources was recombined with presomitic mesoderm. Surface ectoderm from only certain parts of the embryo supported somite epithelialization and elongation. Somite epithelialization induced by ectoderm was correlated with expression of the basic-helix-loop-helix gene Paraxis in the mesoderm. This is consistent with the genetically defined requirement for Paraxis in somite epithelialization. However, trunk ectoderm was able to induce somite epithelialization in the absence of strong Paraxis expression. We conclude that somitogenesis consists of autonomous segmentation patterned by Notch signaling and nonautonomous induction of elongation and epithelialization by surface ectoderm. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:09:13