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Titolo:
Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria
Autore:
Shakil, AO; Kramer, D; Mazariegos, GV; Fung, JJ; Rakela, J;
Indirizzi:
Univ Pittsburgh, Sch Med, Div Gastroenterol & Hepatol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA oenterol & Hepatol, Pittsburgh, PA USA Univ Pittsburgh, Sch Med, Div Crit Care Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Div Crit Care Med, Pittsburgh, PA USA Univ Pittsburgh, Sch Med, Div Transplantat Surg, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Transplantat Surg, Pittsburgh, PA USA Univ Pittsburgh, Sch Med, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Transplantat Inst, Pittsburgh, PA USA
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 2, volume: 6, anno: 2000,
pagine: 163 - 169
SICI:
1527-6465(200003)6:2<163:ALFCFO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; INTERNATIONAL NORMALIZED RATIO; EARLY INDICATORS; UNITED-STATES; C VIRUS; TRANSPLANTATION; BIOPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Shakil, AO UPMC Presbyterian, Div Gastroenterol & Hepatol, Mezzanine Level,C Wing PUH,200 Lothrop St, Pittsburgh, PA 15213 USA UPMC Presbyterian Mezzanine Level,C Wing PUH,200 Lothrop St Pittsburgh PA USA 15213
Citazione:
A.O. Shakil et al., "Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria", LIVER TRANS, 6(2), 2000, pp. 163-169

Abstract

Acute liver failure (ALF) is an uncommon condition associated with high morbidity and mortality. We performed a retrospective analysis of patients evaluated for ALE The aim of our study is to determine the clinical features and outcome of such patients and to assess the validity of King's College Hospital (KCH) prognostic criteria, One hundred seventy-seven patients were evaluated for ALF during a period of 13 years. Mean age was 39 years, and 63% were women. The causes included viral hepatitis (31%), acetaminophen toxicity (19%), idiosyncratic drug reactions (12%), miscellaneous causes (11%), and an indeterminate group (28%), Twenty-live patients (14%) recovered with medical therapy (group I), 65 patients (37%) died without orthotopic Liver transplantation (OLT; group II), and 87 patients (49%) underwent OLT (group III). patients in group II were older and often had advanced encephalopathy, whereas those in group I had less hyperbilirubinemia and often had hyperacute failure. KCH criteria had high specificity and positive predictivevalue but low negative predictive value for a poor outcome. We conclude that early prognostication is needed in patients with ALF to assist decision making regarding OLT. The fulfillment of KCH criteria usually predicts a poor outcome, but a lack of fulfillment does not predict survival. Copyright (C) 2000 by the American Association for the Study of liver Diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 01:26:28