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Titolo:
Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in rats
Autore:
Utkan, T; Ulak, G; Yildiran, HG; Yardimoglu, M; Gacar, MN;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ, Fac Med, Dept Histol, TR-41900 Kocaeli, Turkey Kocaeli UnivKocaeli Turkey TR-41900 pt Histol, TR-41900 Kocaeli, Turkey
Titolo Testata:
LIFE SCIENCES
fascicolo: 18, volume: 66, anno: 2000,
pagine: 1705 - 1711
SICI:
0024-3205(2000)66:18<1705:IOTMII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMIDAZOLINE RECEPTOR AGONIST; NITRIC-OXIDE; ACID SECRETION; CLONIDINE; ARGININE; ULCERS;
Keywords:
agmatine; ethanol ulcer; alpha(2)-adrenoceptors; imidazoline receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 , TR-41900 Kocaeli, Turkey
Citazione:
T. Utkan et al., "Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in rats", LIFE SCI, 66(18), 2000, pp. 1705-1711

Abstract

Effects of agmatine, an endogenous metabolite formed by decarboxylation ofL-arginine, on ethanol-induced gastric mucosal injury were investigated inrats. Agmatine at 1 and 10 mg/kg i.p doses significantly increased ethanol-induced gastric mucosal injury. This effect of agmatine was abolished completely by pretreatment with idazoxan, an imidazoline receptor-antagonist and alpha(2) receptor- antagonist, (0.5 mg/kg i.p), partly by yohimbine, an alpha(2) receptor- antagonist, (1 mg/kg i.p) but not by L-arginine, a precursor of nitric oxide, (500 mg/kg i.p). Our results suggest that agmatine hada potent ulcerogenic effect mediated, at least in part, by both alpha(2)-adrenoceptors and imidazoline receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:22:43