Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
How the alpha-hydroxymethylserine residue stabilizes oligopeptide complexes with nickel(II) and copper(II) ions
Autore:
Mlynarz, P; Gaggelli, N; Panek, J; Stasiak, M; Valensin, G; Kowalik-Jankowska, T; Leplawy, ML; Latajka, Z; Kozlowski, H;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Univ Siena, Dipartimento Chim, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 , Dipartimento Chim, I-53100 Siena, Italy Lodz Tech Univ, Inst Organ Chem, PL-90924 Lodz, Poland Lodz Tech Univ Lodz Poland PL-90924 st Organ Chem, PL-90924 Lodz, Poland
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
, volume: 7, anno: 2000,
pagine: 1033 - 1038
SICI:
0300-9246(2000)7:<1033:HTARSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING ABILITY; L-HISTIDINE; PEPTIDE; DIPEPTIDES; AMINO; COMPETITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kozlowski, H Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw F Joliot Curie 14 Wroclaw Poland PL-50383 oland
Citazione:
P. Mlynarz et al., "How the alpha-hydroxymethylserine residue stabilizes oligopeptide complexes with nickel(II) and copper(II) ions", J CHEM S DA, 7, 2000, pp. 1033-1038

Abstract

Potentiometric, spectroscopic and theoretical studies have shown that the alpha-hydroxymethylserine (HmS) residue is a very specific amino acid residue when inserted into a peptide sequence. The theoretical calculations as well as evaluated deprotonation microconstants indicated that in the HmS-HmS-His tripeptide the N-terminal ammonium group is more acidic than the imidazole nitrogen. The hydrogen bond formation between the N-terminal amino group and imidazole nitrogen stabilizes the cyclic conformation of the metal-free peptide. The unusual gain in the 4N complex stability in the copper(II)and nickel(II) complexes with HmS-HmS-His ligands seems to derive from theenhancement of the pi-electron contribution to the metal-amide nitrogen bond.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:46:53