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Titolo:
Antisecretory effects of galanin and its putative antagonists M15, M35 andC7 in the rat stomach
Autore:
Kisfalvi, I; Burghardt, B; Balint, A; Zelles, T; Vizi, ES; Varga, G;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary Semmelweis Univ Med, Dept Surg 3, H-1085 Budapest, Hungary Semmelweis UnivMed Budapest Hungary H-1085 3, H-1085 Budapest, Hungary Semmelweis Univ Med, Dept Oral Biol, H-1085 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1085 ol, H-1085 Budapest, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1, volume: 94, anno: 2000,
pagine: 37 - 42
SICI:
0928-4257(200001/02)94:1<37:AEOGAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; PANCREATIC AMYLASE SECRETION; PHARMACOLOGICAL CHARACTERIZATION; GASTROINTESTINAL-TRACT; ACETYLCHOLINE-RELEASE; RECEPTOR ANTAGONISTS; MOLECULAR-CLONING; CONSCIOUS RATS; SMOOTH-MUSCLE; FUNDUS STRIPS;
Keywords:
galanin; receptor; acid secretion; gastric emptying; chimeric analogues;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Varga, G Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 apest, Hungary
Citazione:
I. Kisfalvi et al., "Antisecretory effects of galanin and its putative antagonists M15, M35 andC7 in the rat stomach", J PHYSL-PAR, 94(1), 2000, pp. 37-42

Abstract

The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin(1-12)-Pro-substanceP(5-11)-amide), M35 (galanin(1-12)-Pro-bradykinin(2-9)-amide) and C7 (galanin(1-12)-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol.kg(-1).h(-1), i.v.) in a dose-dependent manner (ID50 = 1.8 +/- 0.3 nmol.kg(-1)h(-1)). When 9 nmol.kg(-1)h(-1) galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol.kg(-1).h(-1)) did not modify responses of the stomach to galanin, but actedas agonists of galanin on acid secretion. Neither galanin nor its putativeantagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the re,regulationof gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd. Published by Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:12:19