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Titolo:
Stimulatory effect of dibutyryl cyclic GMP on acid secretion in mouse isolated stomach and on histamine release in gastric mucosal cells
Autore:
Horie, S; Hasebe, K; Koshikawa, H; Tsuchiya, S; Yano, S; Watanabe, K;
Indirizzi:
Chiba Univ, Fac Pharmaceut Sci, Dept Drug Evaluat & Toxicol Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol & Pharmacotherapeut, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 & Pharmacotherapeut, Chiba 2638522, Japan
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1, volume: 94, anno: 2000,
pagine: 25 - 29
SICI:
0928-4257(200001/02)94:1<25:SEODCG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROCHROMAFFIN-LIKE CELLS; NITRIC-OXIDE DONOR; VAGAL-STIMULATION; ENDOCRINE-CELLS; PARIETAL-CELLS; INHIBITOR; OUABAIN; RATS;
Keywords:
gastric acid secretion; enterochromaffin-like cell; histamine; cyclic AMP; cyclic GMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Horie, S Chiba Univ, Fac Pharmaceut Sci, Dept Drug Evaluat & Toxicol Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 rmacol Lab, Chiba 2638522, Japan
Citazione:
S. Horie et al., "Stimulatory effect of dibutyryl cyclic GMP on acid secretion in mouse isolated stomach and on histamine release in gastric mucosal cells", J PHYSL-PAR, 94(1), 2000, pp. 25-29

Abstract

We previously reported that endogenous nitric oxide (NO) is involved in the peripheral control of gastric acid secretion induced by some secretagogues, and that endogenous NO is involved in the acid secretion process via histamine release from histamine-containing cells. However, the stimulus-secretion coupling in the cells remains to be clarified. In the present study, we investigated the effect of dibutyryl cyclic GMP on gastric acid secretionin mouse isolated stomach and on histamine release in gastric mucosal cells, in comparison with those of dibutyryl cyclic AMP. Dibutyryl cyclic GMP (300 mu M) produced a slight but significant increase of gastric acid secretion, which was completely inhibited by the histamine-H2 receptor antagonistfamotidine. In contrast, dibutyryl cyclic GMP (1 mM) markedly inhibited histamine-induced acid secretion. Dibutyryl cyclic AMP (100 mu M) produced a sustained increase of gastric acid secretion. The pretreatment with famotidine partially inhibited dibutyryl cyclic AMP-induced gastric acid secretion. Dibutyryl cyclic GMP and dibutyryl cyclic AMP significantly increased thehistamine release from gastric mucosal cells. These results suggest that both intraceLluIar cyclic GMP and cyclic AMP act as second messengers for histamine release in the histamine-containing cells, probably ECL cells. On the other hand, in gastric parietal cells, cyclic AMP has a stimulatory effect on gastric acid secretion, whereas cyclic GMP has an inhibitory effect. (C) 2000 Elsevier Science Ltd. Published by editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:16:41