Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Food intake abolishes the response of rat jejunal Na+,K+-ATPase to dopamine
Autore:
Lucas-Teixeira, V; Vieira-Coelho, MA; Soares-da-Silva, P;
Indirizzi:
Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac MedPorto Oporto Portugal P-4200 Therapeut, P-4200 Oporto, Portugal
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 4, volume: 130, anno: 2000,
pagine: 877 - 881
SICI:
0022-3166(200004)130:4<877:FIATRO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-SALT DIET; RENAL DOPAMINE; GASTROINTESTINAL-TRACT; PROXIMAL TUBULE; RECEPTORS; 5-HYDROXYTRYPTAMINE; HYPERTENSION;
Keywords:
dopamine; jejunum; rats; Na+,K+-ATPase; food intake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Soares-da-Silva, P Fac Med Porto, Inst Pharmacol & Therapeut, P-4200 Oporto, Portugal Fac Med Porto Oporto Portugal P-4200 Oporto, Portugal
Citazione:
V. Lucas-Teixeira et al., "Food intake abolishes the response of rat jejunal Na+,K+-ATPase to dopamine", J NUTR, 130(4), 2000, pp. 877-881

Abstract

The aim of the present study was to evaluate whether the sensitivity of jejunal Na+,K+-ATPase to inhibition by dopamine (DA) in young rats is relatedto the type of food (breast milk vs. solid) or reflects a developmental adaptation. When 18-d-old rats were separated from their dams and fed solid food (the same used to feed adult rats) for 2 d, intestinal Na+,K+-ATPase activity was significantly greater than that of breast-fed pups of the same age (20 d) (127 +/- 8 vs. 52 +/- 4 nmol Pi . mg protein(-1) . min(-1); P < 0.05). Activity in rats fed solid food was insensitive to inhibition by 1 mumol/L DA. Na+ ,K+-ATPase activity in 60-d-old rats (117.4 +/- 4.2 nmol Pi . mg protein(-1) . min(-1)) was also higher (P < 0.05) than in breast-fed rats, and DA (1 mu mol/L) did not inhibit enzyme activity. The B-max value for binding of [H-3]-Sch 23390 in 20-d-old breast-fed rats did not differ from that in age-matched rats fed a solid food for 2 d and or that in 60-d-old rats. Levels of DA, but not L-3,4-dihydroxyphenylalanine and amine metabolites, in the jejunal mucosa of 20-d-old rats that had eaten solid food for2 d were 60% lower than in age-matched rats, breast-fed rats, and not different from those in the jejunal mucosa of 60-d-old rats fed the solid food. We conclude that in adult rats, in contrast to in young rats, DA does not inhibit jejunal Na+,K+-ATPase activity, and food intake in young rats playsan important role in the development of the insensitivity of Na+,K+-ATPaseactivity to DA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:03:52