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Titolo:
Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls
Autore:
Mochizuki, H; Oda, H; Yokogoshi, H;
Indirizzi:
Univ Shizouka, Sch Food & Nutr Sci, Shizouka 4228526, Japan Univ ShizoukaShizouka Japan 4228526 & Nutr Sci, Shizouka 4228526, Japan Nagoya Univ, Dept Appl Mol Biosci, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 osci, Nagoya, Aichi 4648601, Japan
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 4, volume: 130, anno: 2000,
pagine: 873 - 876
SICI:
0022-3166(200004)130:4<873:DTAAAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FED PCB; CHOLESTEROL; XENOBIOTICS; ENZYMES; LIVER; METHIONINE; INDUCTION; PROTEIN; DAMAGE;
Keywords:
taurine; polychlorinated biphenyls; ascorbic acid; cytochrome P-450; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Yokogoshi, H Univ Shizouka, Sch Food & Nutr Sci, Shizouka 4228526, Japan Univ Shizouka Shizouka Japan 4228526 hizouka 4228526, Japan
Citazione:
H. Mochizuki et al., "Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls", J NUTR, 130(4), 2000, pp. 873-876

Abstract

The effect of dietary taurine on ascorbic acid metabolism and hepatic drug-metabolizing enzymes was investigated in rats fed diets containing polychlorinated biphenyls (PCB) to determine whether taurine has an adaptive and protective function in xenobiotic-treated animals. Young male Wistar rats (60 g) were fed diets containing 0 or 0.2 g/kg diet PCB with or without 30 g/kg diet of taurine for 14 d. The rats fed the PCB-containing diets had greater liver weight, higher ascorbic acid concentrations in the liver and spleen and greater hepatic cytochrome P-450 contents than control rats that were not treated with PCB (P < 0.01). In PCB-fed rats, urinary ascorbic acid excretion was enhanced, and serum cholesterol concentration (especially HDL-cholesterol) was significantly elevated compared with those in control rats. Dietary taurine significantly potentiated the increases in the urinary excretion of ascorbic acid and the rise in the levels of cytochrome P-450 which were caused by PCB treatment. On the other hand, the supplementation of taurine to control diet did not alter these variables. Taurine may enhance the hepatic drug-metabolizing systems, leading to the stimulation of the ascorbic acid metabolism in rats fed diets containing PCB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:43:06