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Titolo:
Neuronal correlates of fear in the lateral amygdala: Multiple extracellular recordings in conscious cats
Autore:
Pare, D; Collins, DR;
Indirizzi:
Univ Laval, Fac Med, Dept Physiol, Neurophysiol Lab, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 Quebec City, PQ G1K 7P4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 20, anno: 2000,
pagine: 2701 - 2710
SICI:
0270-6474(20000401)20:7<2701:NCOFIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM CORE; NON-CHOLINERGIC NEURONS; CENTRAL NUCLEUS NEURONS; LONG-TERM POTENTIATION; PROJECTION NEURONS; TEMPORAL-LOBE; THETA-RHYTHM; ELECTROPHYSIOLOGICAL CHARACTERISTICS; EMOTIONAL RESPONSES; ENTORHINAL CORTEX;
Keywords:
amygdala; fear; multisite recording; lateral amygdala; learning; memory; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Pare, D Univ Laval, Fac Med, Dept Physiol, Neurophysiol Lab, Quebec City, PQ G1K 7P4, Canada Univ Laval Quebec City PQ Canada G1K 7P4 City, PQ G1K 7P4, Canada
Citazione:
D. Pare e D.R. Collins, "Neuronal correlates of fear in the lateral amygdala: Multiple extracellular recordings in conscious cats", J NEUROSC, 20(7), 2000, pp. 2701-2710

Abstract

Much data implicates the amygdala in the expression and learning of fear. Yet, few studies have examined the neuronal correlates of fear in the amygdala. This study aimed to determine whether fear is correlated to particularactivity patterns in the lateral amygdaloid (LA) nucleus. Cats, chronically implanted with multiple microelectrodes in the LA and a catheter in the femoral artery, learned that a series of tones interrupted by a period of silence (5 sec) preceded the administration of a footshock. During the silentperiod, their blood pressure increased, indicating that they anticipated the noxious stimulus. In parallel, the firing rate of LA neurons doubled, and the discharges of simultaneously recorded cells became more synchronized. Moreover, cross-correlation of focal LA waves revealed a significant increase in synchrony restricted to the theta band. In keeping with this, perievent histograms of neuronal discharges revealed rhythmic changes in the firing probability of LA neurons in relation to focal theta waves. Finally, theresponsiveness of LA cells to the stimuli predicting the footshock (the tones) increased during the trials, whereas responses to unrelated stimuli (perirhinal shocks) remained stable. Thus, during the anticipation of noxiousstimuli, a state here defined anthropomorphically as fear, the firing rateof LA neurons increases, and their discharges become more synchronized through a modulation at the theta frequency. The presence of theta oscillations in the LA might facilitate cooperative interactions between the amygdala and cortical areas involved in memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:43:07