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Titolo:
Tridimensional personality questionnaire and treatment response in major depressive disorder: a negative study
Autore:
Newman, JR; Ewing, SE; McColl, RD; Borus, JS; Nierenberg, AA; Pava, J; Fava, M;
Indirizzi:
Massachusetts Gen Hosp, Depress Clin & Res Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA McLean Hosp, Belmont, MA 02178 USA McLean Hosp Belmont MA USA 02178McLean Hosp, Belmont, MA 02178 USA
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1-3, volume: 57, anno: 2000,
pagine: 241 - 247
SICI:
0165-0327(200001/03)57:1-3<241:TPQATR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT RESPONSE; TEMPERAMENT; STATES; MOOD; DESIPRAMINE; FLUOXETINE; DIMENSIONS; TRAITS;
Keywords:
depression; fluoxetine; tridimensional personality questionnaire; treatment response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Newman, JR Childrens Hosp, 300 Longwood Ave,Fegan 8, Boston, MA 02115 USA Childrens Hosp 300 Longwood Ave,Fegan 8 Boston MA USA 02115 USA
Citazione:
J.R. Newman et al., "Tridimensional personality questionnaire and treatment response in major depressive disorder: a negative study", J AFFECT D, 57(1-3), 2000, pp. 241-247

Abstract

Background: Recent studies have found that the Tridimensional Personality Questionnaire can be used to help predict antidepressant treatment responsein depressed outpatients. As this finding could be of great clinical importance, we attempted to replicate these findings. Methods: Our study included 199 outpatients with major depressive disorder in an 8-week open trial with fluoxetine 20 mg/day. The Tridimensional Personality Questionnaire (TPQ)was administered to all patients before treatment. Results: There was a significant correlation between pre-treatment scores on the TPQ subscale of harm avoidance and severity of depression at baseline as determined by Hamilton Depression Rating Scale-17 (HAM-D-17) scores. There was no correlation of harm avoidance scores and percent improvement of HAM-D-17 after treatment with fluoxetine, Then was also no correlation of baseline HAM-D-17 scoresor percent improvement with the subscales of reward dependence and noveltyseeking. Limitations: Our study's limitations include a possible selectionbias, lack of controls and fixed dosing of fluoxetine. Conclusions: In contrast to previous studies, we failed to find a relationship between temperament type as defined by the TPQ and antidepressant response. Our failure toreplicate the findings of other studies may in large par? be related to the use of different classes of antidepressants. Further studies using similar antidepressants may be helpful to clarify this discrepancy. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 20/09/20 alle ore 19:35:10