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Titolo:
Motor and cognitive aspects of motor retardation in depression
Autore:
Caligiuri, MP; Ellwanger, J;
Indirizzi:
Univ Calif San Diego, Dept Psychiat 0603, Movement Disorders Lab, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 rs Lab, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1-3, volume: 57, anno: 2000,
pagine: 83 - 93
SICI:
0165-0327(200001/03)57:1-3<83:MACAOM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; PSYCHOMOTOR RETARDATION; NEGATIVE SYMPTOMS; MAJOR DEPRESSION; BRADYKINESIA; MOVEMENTS; DOPAMINE;
Keywords:
depression; motor retardation; psychomotor impairment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Caligiuri, MP Univ Calif San Diego, Dept Psychiat 0603, Movement DisordersLab, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 la, CA 92093 USA
Citazione:
M.P. Caligiuri e J. Ellwanger, "Motor and cognitive aspects of motor retardation in depression", J AFFECT D, 57(1-3), 2000, pp. 83-93

Abstract

Background: Motor retardation is a common feature of major depressive disorder having potential prognostic and etiopathological significance. According to DSM-IV, depressed patients who meet criteria for psychomotor retardation, must exhibit motor slowing of sufficient severity to be observed by others. However, overt presentations of motor slowing cannot distinguish slowness due to cognitive factors from slowness due to neuromotor disturbances. Methods: We examined cognitive and neuromotor aspects of motor slowing in 36 depressed patients to test the hypothesis that a significant proportion of patients exhibit motor programming disturbances in addition to psychomotor impairment. A novel instrumental technique was used to assess motor programming in terms of the subject's ability to program movement velocity as afunction of movement distance. A traditional psychomotor battery was combined with an instrumental measure of reaction time to assess the cognitive aspects of motor retardation. Results: The depressed patients exhibited significant impairment on the velocity scaling measure and longer reaction times compared with nondepressed controls. Approximately 40% of the patients demonstrated abnormal psychomotor function as measured by the traditional battery; whereas over 60% exhibited some form of motor slowing as measured by the instruments. Approximately 40% of the patients exhibited parkinsonian-like motor programming deficits. A five-factor model consisting of motor measures predicted diagnosis among bipolar and unipolar depressed patients with 100% accuracy. Limitations: The ability of motor measures to discriminatebipolar from unipolar patients must be viewed with caution considering therelatively small sample size of bipolar patients. Conclusions: These findings suggest that a subgroup of depressed patients exhibit motor retardationthat is behaviorally similar to parkinsonian bradykinesia and may stem from a similar disruption within the basal ganglia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:06:30