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Titolo:
Effect of San-Ao-Tang on immediate and late airway response and leukocyte infiltration in asthmatic guinea pigs
Autore:
Kao, ST; Yeh, TJ; Hsieh, CC; Yeh, FT; Lin, JG;
Indirizzi:
Sch Post Baccalaureate Chinese Med, Dept Immunol & Cellular Physiol, Taichung, Taiwan Sch Post Baccalaureate Chinese Med Taichung Taiwan ol, Taichung, Taiwan China Med Coll Hosp, Taichung, Taiwan China Med Coll Hosp Taichung Taiwan ina Med Coll Hosp, Taichung, Taiwan China Med Coll, Res Inst Chinese Med, Taichung, Taiwan China Med Coll Taichung Taiwan , Res Inst Chinese Med, Taichung, Taiwan
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 1, volume: 22, anno: 2000,
pagine: 143 - 162
SICI:
0892-3973(2000)22:1<143:EOSOIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL CHEMOTACTIC ACTIVITY; LATE-PHASE BRONCHOCONSTRICTION; BRONCHOALVEOLAR LAVAGE FLUID; LUNG MAST-CELLS; BRONCHIAL RESPONSIVENESS; TOLUENE DIISOCYANATE; SODIUM CROMOGLYCATE; GLYCYRRHETINIC ACID; ALLERGEN CHALLENGE; HOUSE DUST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Kao, ST Sch Post Baccalaureate Chinese Med, Dept Immunol & Cellular Physiol, Taichung, Taiwan Sch Post Baccalaureate Chinese Med Taichung Taiwan hung, Taiwan
Citazione:
S.T. Kao et al., "Effect of San-Ao-Tang on immediate and late airway response and leukocyte infiltration in asthmatic guinea pigs", IMMUNOPH IM, 22(1), 2000, pp. 143-162

Abstract

San-Ao-Tang (SAT), a traditional Chinese medicines, has been used to treatpatients with the bronchial asthma for several centuries. However, the therapeutic mechanisms of this Chinese medicine are still far from clear. To understand the mechanism of antiasthmatic property of SAT, a guinea pig model of allergic asthma was used to investigate the effects of SAT on Dermatophagoides pteronyssinus-induced immediate and late asthmatic responses and airway inflammation. Our results showed that administration of SAT (10g/kg) extracts significantly inhibited the antigen induced immediate asthmatic responses (IAR) in actively sensitized guinea pig. Examination of bronchoalveolar lavage fluid (BALF) revealed that SAT significantly inhibited the increase in neutrophil in the airway at 1, 2, 4, 6, 8 hr after antigen challenge. Histopathologic examination showed SAT suppressed the neutrophil infiltration into lung tissue. These results suggest that the antiasthmatic effectof SAT be mainly due to its bronchodilator effect and its ability to inhibit the neutrophil into the airway. The precise mechanism of action of SAT in asthma remains to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 10:39:16