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Titolo:
A single amino acid substitution causes loss of expression of a MICA allele
Autore:
Li, ZH; Groh, V; Strong, RK; Spies, T;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA
Titolo Testata:
IMMUNOGENETICS
fascicolo: 3, volume: 51, anno: 2000,
pagine: 246 - 248
SICI:
0093-7711(200003)51:3<246:ASAASC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; RECOGNITION; MOLECULES;
Keywords:
MHC; MICA; tumor cell lines; null allele;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Spies, T Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr 1100 Fairview Ave N Seattle WA USA 98109
Citazione:
Z.H. Li et al., "A single amino acid substitution causes loss of expression of a MICA allele", IMMUNOGENET, 51(3), 2000, pp. 246-248

Abstract

The human major histocompatibility complex ((MHC) class I homologues MICA and MICE are stress-inducible surface molecules that are not associated with beta(2)-microglobulin and peptides, are expressed in intestinal epithelium and epithelial tumors, and are recognized by V(delta)1 gamma delta T cells, a subset of gamma delta T cells that is enriched in epithelial sites (Bahram et al. 1994; Groh et al. 1996, 1998, 1999). Analogous to the interactions of MHC class I molecules with inhibitory or activating natural killer (NK) cell receptors that are expressed on NK cells and T cells (Lanier 1998,MICA/B are ligands for an activating receptor, NKG2D, which is expressed on most NK cells, CD8(+) alpha beta T cells and gamma delta T cells (Bauer et al. 1999).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:59:18