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Titolo:
Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation cirrhosis
Autore:
Pardo, A; Bartoli, R; Lorenzo-Zuniga, V; Planas, R; Vinado, B; Riba, J; Cabre, E; Santos, J; Luque, T; Ausina, V; Gassull, MA;
Indirizzi:
Hosp Univ Germans Trias & Pujol, Dept Gastroenterol, Badalona 08916, SpainHosp Univ Germans Trias & Pujol Badalona Spain 08916 dalona 08916, Spain Hosp Univ Germans Trias & Pujol, Dept Microbiol, Badalona 08916, Spain Hosp Univ Germans Trias & Pujol Badalona Spain 08916 dalona 08916, Spain Hosp Univ Germans Trias & Pujol, Dept Nucl Med, Badalona 08916, Spain HospUniv Germans Trias & Pujol Badalona Spain 08916 dalona 08916, Spain
Titolo Testata:
HEPATOLOGY
fascicolo: 4, volume: 31, anno: 2000,
pagine: 858 - 863
SICI:
0270-9139(200004)31:4<858:EOCOIB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC LYMPH-NODES; SMALL-BOWEL MOTILITY; LIVER-CIRRHOSIS; PERITONITIS; RATS; NORFLOXACIN; DECONTAMINATION; MICROFLORA; RESISTANCE; CIRRHOTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Planas, R Hosp Univ Germans Trias & Pujol, Dept Gastroenterol, Carretera Canyet S-N,Badalona 08916, Spain Hosp Univ Germans Trias & Pujol Carretera Canyet S-N Badalona Spain 08916
Citazione:
A. Pardo et al., "Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation cirrhosis", HEPATOLOGY, 31(4), 2000, pp. 858-863

Abstract

Deranged intestinal motility, which occurs in cirrhosis, may facilitate the development of intestinal bacterial overgrowth (IBO), which can lead to bacterial translocation (BT), To assess the effect of cisapride on IBO and BT in cirrhosis, cirrhotic rats received cisapride or a placebo for 7 days, and measurements of jejunal bacterial content and BT studies were performed. In addition, jejunal fluid from 46 cirrhotic patients was obtained for quantitative bacterial culture. Those patients in whom gram-negative IBO was detected were randomized to receive or not to receive cisapride (20 mg twice per day) for 1 week. Cisapride significantly reduced IBO in cirrhotic rats. In addition, no BT was documented in treated animals, whereas it occurred in 40% in nontreated cirrhotic rats. Total IBO was documented in 23 of 46cirrhotic patients, which was caused by gram-negative organisms in 10 cases. Orocecal transit time (OCT) significantly decreased after cisapride therapy, and was associated with the abolishment of bacterial overgrowth causedby gram-negative organisms in 4 out of 5 treated patients, whereas it persisted in nontreated cases. Cisapride administration to cirrhotic rats resulted in a reduction of the IBO, which is associated with a marked decrease in BT. On the other hand, cisapride facilitates the abolition of IBO caused by gram-negative organisms in cirrhotic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:13:30