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Titolo:
Intermediate filament protein synemin is transiently expressed in a subsetof astrocytes during development
Autore:
Sultana, S; Sernett, SW; Bellin, RM; Robson, RM; Skalli, O;
Indirizzi:
Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA Univ IllinoisChicago IL USA 60612 nat & Cell Biol, Chicago, IL 60612 USA Iowa State Univ, Dept Biochem Biophys & Mol Biol, Muscle Biol Grp, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 ol, Muscle Biol Grp, Ames, IA 50011 USA Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 Univ, Dept Anim Sci, Ames, IA 50011 USA
Titolo Testata:
GLIA
fascicolo: 2, volume: 30, anno: 2000,
pagine: 143 - 153
SICI:
0894-1491(200004)30:2<143:IFPSIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT PROTEIN; POSTNATAL RAT FOREBRAIN; VIMENTIN FILAMENTS; SUBVENTRICULAR ZONE; RADIAL GLIA; SKELETAL-MUSCLE; CEREBRAL-CORTEX; NERVOUS-SYSTEM; CELLS; IDENTIFICATION;
Keywords:
glia; cortex; synemin; GFAP; nestin; vimentin; intermediate filament;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Skalli, O Univ Illinois, Dept Anat & Cell Biol, 808 S Wood St,M-C 512, Chicago, IL 60612 USA Univ Illinois 808 S Wood St,M-C 512 Chicago IL USA 60612612 USA
Citazione:
S. Sultana et al., "Intermediate filament protein synemin is transiently expressed in a subsetof astrocytes during development", GLIA, 30(2), 2000, pp. 143-153

Abstract

Synemin, a developmentally regulated protein first described in muscle cells, has recently been recognized as an intermediate filament (IF) protein. Because IF proteins are invaluable markers of cell origin within the nervous system, we were interested in determining the expression pattern of synemin in the brain. Our results show that, during development of the rat cortex, synemin is expressed only in a subpopulation of astrocytic cells expressing GFAP as well as vimentin and nestin. Uhlike GFAP, however, synemin is not expressed in mature astrocytes and, unlike vimentin and nestin, synemin is not present in astrocytic precursors before GFAP expression. Taken together with morphological evidence, the time course of synemin expression, as determined by Western blotting, suggests that synemin is expressed in radial glial cells undergoing morphological transformation into astrocytes. Studies of synemin expression in vitro demonstrate that, early in primary culture, the majority of polygonal astrocytes are derived from synemin(+) radialglial cells. With time in culture, however, polygonal astrocytes either stop expressing synemin or are overgrown by cells not expressing synemin. Theunique pattern of synemin expression, both in vivo and in vitro, suggests that the use of synemin as a marker will add a new dimension to studies of astrocytic differentiation. GLIA 30:143-153, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 14:53:04