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Titolo:
MAO-A and MAO-B activities in rat striatum, frontal cortex and liver are unaltered after long-term treatment with fluvoxamine and desipramine
Autore:
Silver, H; Youdim, MBH;
Indirizzi:
Hosp Psychiat, Flugelman Mazra, Doar Na Ashrat, Israel Hosp Psychiat DoarNa Ashrat Israel elman Mazra, Doar Na Ashrat, Israel Technion Israel Inst Technol, Fac Med, Haifa, Israel Technion Israel Inst Technol Haifa Israel chnol, Fac Med, Haifa, Israel Rappaport Family Res Inst, Eve Topf, Israel Rappaport Family Res Inst EveTopf Israel ly Res Inst, Eve Topf, Israel Natl Parkinson Fdn Ctr Neurodegenerat Dis, Haifa, Israel Natl Parkinson Fdn Ctr Neurodegenerat Dis Haifa Israel s, Haifa, Israel
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 10, anno: 2000,
pagine: 125 - 128
SICI:
0924-977X(200003)10:2<125:MAMAIR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE; TYROSINE-HYDROXYLASE; ANTIDEPRESSANT DRUGS; GENE-EXPRESSION; MESSENGER-RNA; BRAIN; 5-HYDROXYTRYPTAMINE; INHIBITION; MODEL;
Keywords:
MAO desipramine fluvoxamine; rats; chronic treatment; antidepressant; mechanism of action; platelets; brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Silver, H Hosp Psychiat, Flugelman Mazra, Doar Na Ashrat, Israel Hosp Psychiat Doar Na Ashrat Israel a, Doar Na Ashrat, Israel
Citazione:
H. Silver e M.B.H. Youdim, "MAO-A and MAO-B activities in rat striatum, frontal cortex and liver are unaltered after long-term treatment with fluvoxamine and desipramine", EUR NEUROPS, 10(2), 2000, pp. 125-128

Abstract

In the course of investigating the mechanisms underlying the beneficial effect of fluvoxamine augmentation on negative symptoms of schizophrenia, theauthors found a reduction in human platelet monoamine oxidase-B activity after 5 weeks of treatment. This unexpected finding raised the possibility that MAO activity may be one of the factors altered by chronic tricyclic or SSRI antidepressant treatment. The current study examined the effect of long-term administration, up to 6 weeks, of fluvoxamine, desipramine or salineon MAO-A and MAO-B activities in rat striatum, frontal cortex and liver. No differences were noted between drug-treated groups and their saline-treated controls. The hypothesis that long-term treatment with tricyclic and SSRI antidepressants alters MAO activity was not supported. MAO is not among proteins whose activity may be altered by chronic tricyclic or SSRI antidepressant treatment. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:25:19