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Titolo:
5-HT3 receptor antagonists and anxiety; a preclinical and clinical review
Autore:
Olivier, B; van Wijngaarden, I; Soudijn, W;
Indirizzi:
Univ Utrecht, Rudolf Magnus Inst, Fac Pharm, Dept Psychopharmacol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Psychopharmacol, Utrecht, Netherlands PsychoGen Inc, Hawthorn, NY 10532 USA PsychoGen Inc Hawthorn NY USA 10532PsychoGen Inc, Hawthorn, NY 10532 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Leiden Amsterdam Ctr Drug Res, Leiden, Netherlands Leiden Amsterdam Ctr Drug Res Leiden Netherlands s, Leiden, Netherlands
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 2, volume: 10, anno: 2000,
pagine: 77 - 95
SICI:
0924-977X(200003)10:2<77:5RAAAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; DISCRIMINATIVE STIMULUS PROPERTIES; POTENTIATED STARTLE PARADIGM; ULTRASONIC DISTRESS VOCALIZATIONS; ISOLATION-INDUCED AGGRESSION; STRESS-INDUCED HYPERTHERMIA; RATS RATTUS-NORVEGICUS; NON-OPIOID ANALGESIA; GATED ION-CHANNEL; ADULT MALE-RATS;
Keywords:
5-HT3 receptor; 5-HT1A receptor; 5-HT3 receptor antagonists; benzodiazepines; anxiety; animal models; conflict; potentiated startle; periaquaductal gray stimulation; conditioned place preference; defensive burying; ultrasonic pup vocalization; adult ultrasonic vocalization; defeat-induced analgesia; elevated plus-maze; social interaction; light-dark exploration; stress-induced hyperthermia; drug discrimination; generalized anxiety disorder; panic disorder;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
229
Recensione:
Indirizzi per estratti:
Indirizzo: Olivier, B Univ Utrecht, Rudolf Magnus Inst, Fac Pharm, Dept Psychopharmacol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands macol, Utrecht, Netherlands
Citazione:
B. Olivier et al., "5-HT3 receptor antagonists and anxiety; a preclinical and clinical review", EUR NEUROPS, 10(2), 2000, pp. 77-95

Abstract

The present paper reviews the evidence for anxiolytic activity of 5-HT3 receptor antagonists in animal models of anxiety and in clinical trials in humans. Compared to the established anxiolytics (benzodiazepine receptor agonists and, to a lesser extent, 5-HT1A receptor agonists) 5-HT3 receptor antagonists display a different anxiolytic profile, They are anxiolytic in a limited number of animal anxiety models. If active, they often are very potent and display bell-shaped dose response curves, whereas the ratio between therapeutic activity and side effects appears remarkably large. 5-HT3 receptor antagonists remain active after chronic dosing and no indications for tolerance, dependence or rebound effects were found, which seems to make these drugs an attractive alternative to the benzodiazepines, However, the large body of animal data indicating a complete lack of psychotropic activity of 5-HT3 receptor antagonists weakens the prediction of anxiolytic activity in these drugs. Human data an also controversial; some investigators have reported positive effects in anxiety disorders (panic disorder, GAD), othersdid not. It can be concluded that 5-HT3 receptor antagonists do not represent a breakthrough in the treatment of various anxiety disorders, as initially suggested. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 01/04/20 alle ore 10:46:21