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Titolo:
Inhibitors of the kynurenine pathway
Autore:
Stone, TW;
Indirizzi:
Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 2, volume: 35, anno: 2000,
pagine: 179 - 186
SICI:
0223-5234(200002)35:2<179:IOTKP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; GLYCINE BINDING-SITE; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID RECEPTORS; NMDA RECEPTOR; QUINOLINIC ACID; 5,7-DICHLOROKYNURENIC ACID; ANTICONVULSANT ACTIVITY; RAT-BRAIN; IN-VIVO;
Keywords:
kynurenines; quinolinic acid; kynurenic acid; glutamate; NMDA; N-methyl-D-aspartate; neuroprotection; stroke; neurodegeneration;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Stone, TW Univ Glasgow, Inst Biomed & Life Sci, W Med Bldg, Glasgow G12 8QQ, Lanark,Scotland Univ Glasgow W Med Bldg Glasgow Lanark Scotland G12 8QQ Scotland
Citazione:
T.W. Stone, "Inhibitors of the kynurenine pathway", EUR J MED C, 35(2), 2000, pp. 179-186

Abstract

Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors. The commercial development of the kynurenine pathway hasincluded the use of analogues of kynurenic acid as antagonists at glutamate receptors. A second has been to use prodrugs of kynurenic acid or its analogues. Alternatively, it is proving possible to interfere directly with the kynurenine pathway to block the synthesis of quinolinic acid and promote the formation of kynurenic acid. This change yields neuroprotectant and anticonvulsant compounds. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:56:24