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Titolo:
Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study
Autore:
Philip, BK; Pearman, MH; Kovac, AL; Chelly, JE; Wetchler, BV; McKenzie, R; Monk, TG; Dershwitz, M; Mingus, M; Sung, YF; Hahne, WF; Brown, RA;
Indirizzi:
Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Pain Med, Boston, MA 02115 USA Baptist Med Ctr, Columbia, SC USA Baptist Med Ctr Columbia SC USABaptist Med Ctr, Columbia, SC USA Univ Kansas, Med Ctr, Kansas City, KS 66103 USA Univ Kansas Kansas City KS USA 66103 , Med Ctr, Kansas City, KS 66103 USA Univ Texas, Houston, TX USA Univ Texas Houston TX USAUniv Texas, Houston, TX USA Methodist Med Ctr Illinois, Peoria, IL USA Methodist Med Ctr Illinois Peoria IL USA ed Ctr Illinois, Peoria, IL USA Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 ns Hosp, Pittsburgh, PA 15213 USA Washington Univ Hosp, St Louis, MO USA Washington Univ Hosp St Louis MO USA hington Univ Hosp, St Louis, MO USA Massachusetts Gen Hosp, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Gen Hosp, Boston, MA 02114 USA Mt Sinai Ctr, New York, NY USA Mt Sinai Ctr New York NY USAMt Sinai Ctr, New York, NY USA ASC Emory Clin, Atlanta, GA USA ASC Emory Clin Atlanta GA USAASC Emory Clin, Atlanta, GA USA Hoechst Marion Roussel, Kansas City, MO USA Hoechst Marion Roussel KansasCity MO USA n Roussel, Kansas City, MO USA
Titolo Testata:
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
fascicolo: 1, volume: 17, anno: 2000,
pagine: 23 - 32
SICI:
0265-0215(200001)17:1<23:DFTPOP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS DOLASETRON; GYNECOLOGIC SURGERY; ONDANSETRON; BLIND; CISPLATIN; MESYLATE; EMESIS; WOMEN;
Keywords:
anti-emetic; dolasetron; nausea; emesis; 5-HT3 antagonist; post-operative complications, postoperative nausea and vomiting; outpatient surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Philip, BK Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 115 USA
Citazione:
B.K. Philip et al., "Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study", EUR J ANAES, 17(1), 2000, pp. 23-32

Abstract

In a multicentre, randomized, double-blind, placebo-controlled dose-ranging study, 1030 patients undergoing outpatient surgery with general anaesthesia received i.v. dolasetron mesylate (12.5, 25, 50, or 100 mg) or placebo. The principal outcome measure was the proportion of patients who were free of emesis or rescue medication for the 24-h period after the study drug wasgiven; the subsidiary outcome measure was survival time without rescue medication. Effects on nausea were quantified using a visual analogue scale. Compared with placebo, a complete response was significantly higher when allfour dolasetron doses were combined (49% vs. 58%, P = 0.025). In females, dolasetron, 12.5-mg, dolasetron provided maximum clinical benefit (effectiveness compared with adverse events), with no additional benefit in completeresponse rates or nausea visual analogue scale scores at higher doses. No significant differences were observed in complete response for any dolasetron dose in males compared with placebo. The majority of adverse events reported were mild or moderate. Dolasetron provided well-tolerated, safe, and effective prophylaxis for post-operative nausea and vomiting with maximum effectiveness observed at a dose of 12.5 mg.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 01:17:25