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Titolo:
Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus
Autore:
Covolan, L; Mello, LEAM;
Indirizzi:
UNIFESP, Dept Physiol, BR-04023900 Sao Paulo, Brazil UNIFESP Sao Paulo Brazil BR-04023900 BCol, BR-04023900 Sao Paulo, Brazil
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 39, anno: 2000,
pagine: 133 - 152
SICI:
0920-1211(200004)39:2<133:TPONIF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS RECURRENT SEIZURES; LIMBIC STATUS EPILEPTICUS; FUNCTIONAL-ANATOMY; LOBE EPILEPSY; EXPERIMENTAL-MODEL; DARK NEURONS; DAMAGE; RATS; HIPPOCAMPAL; MECHANISMS;
Keywords:
cell injury; animal models; epilepsy; pilocarpine; kainic acid; status epilepticus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Covolan, L UNIFESP, Dept Physiol, Rua Botucatu 862,5 Andar, BR-04023900 Sao Paulo, Brazil UNIFESP Rua Botucatu 862,5 Andar Sao Paulo Brazil BR-04023900 BC
Citazione:
L. Covolan e L.E.A.M. Mello, "Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus", EPILEPSY R, 39(2), 2000, pp. 133-152

Abstract

Systemic administration of pilocarpine and kainic acid (KA) has been extensively used to model temporal lobe epilepsy in rats. Here the regional distribution of selectively vulnerable neurons and the temporal evolution of such neuronal injury after status epilepticus (SE) are compared in both models. Using the silver staining technique of Gallyas, argyrophilic neurons were measured on a 0-3 (least-most) scale in 53 different brain areas. Few neurons were silver-stained 2.5 h after kainate-induced SE, but many silver-stained cells could be seen in most neocortical, hippocampal, amygdaloid and hypothalamic structures for pilocarpine group. In general, 8 or 24 h intervals between SE onset and perfusion times yielded the most intense neuronal silver-impregnation. Pilocarpine-induced neuronal silver impregnation was more prominent than that induced by kainate treatment for many areas in cortex, hippocampus. endopiriform nucleus, amygdaloid complex and hypothalamus. On the other hand, in the thalamus, some cortical areas, claustrum, lateral septum and caudoputamen, kainate-induced neuronal silver staining was also prominent, but occurred later than in pilocarpine-treated animals. Neuronal injury was found in almost the same brain areas in both models of SE butwith different intensity levels and time course profiles. It was suggestedthat such differences in the temporal profile of cell damage should be taken into account when searching for neuroprotective agents. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:31:33