Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero
Autore:
Baraban, SC; Wenzel, HJ; Hochman, DW; Schwartzkroin, PA;
Indirizzi:
Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Neurol Surg, Seattle, WA 98195 USA
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 39, anno: 2000,
pagine: 87 - 102
SICI:
0920-1211(200004)39:2<87:COHCCI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL MIGRATION DISORDERS; INTRACTABLE PARTIAL EPILEPSY; TEMPORAL-LOBE EPILEPSY; CORTICAL DYSPLASIA; ANIMAL-MODEL; SEIZURE SUSCEPTIBILITY; GLUTAMATE-DECARBOXYLASE; ELECTROGRAPHIC SEIZURES; EPILEPTIFORM ACTIVITY; PRENATAL TREATMENT;
Keywords:
dysplasia; electrophysiology; hippocampus; pediatric epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Baraban, SC Univ Calif San Francisco, Dept Neurol Surg, Box 0112,505 Parnassus Ave, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0112,505Parnassus Ave San Francisco CA USA 94143
Citazione:
S.C. Baraban et al., "Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero", EPILEPSY R, 39(2), 2000, pp. 87-102

Abstract

Cortical disorganization represents one of the major clinical findings in many children with medically intractable epilepsy. To study the relationship between seizure propensity and abnormal cortical structure, we have begunto characterize an animal model exhibiting aberrant neuronal clusters (heterotopia) and disruption of cortical lamination. In this model, exposing rats in utero to the DNA methylating agent methylazoxymethanol acetate (MAM; embryonic day 15) disrupts the sequence of normal brain development. In MAM-exposed rats, cells in hippocampal heterotopia exhibit neuronal morphologyand do not stain with immunohistochemical markers for glia. In hippocampalslices from MAM-exposed animals, extracellular field recordings within heterotopia suggest that these dysplastic cell clusters make synaptic connections locally (i.e. within the CA1 hippocampal subregion) and also make aberrant synaptic contact with neocortical cells. Slice perfusion with bicuculline or 4-aminopyridine leads to epileptiform activity in dysplastic cell clusters that can occur independent of input from CA3. Taken together, our findings suggest that neurons within regions of abnormal hippocampal organization are capable of independent epileptiform activity generation, and can project abnormal discharge to a broad area of neocortex, as well as hippocampus. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:43:45