Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparative study of D-002 versus sulfasalazine on acetic acid-induced colitis in rats
Autore:
Noa, M; Carbajal, D; Molina, V; Valdes, S; Mas, R;
Indirizzi:
Natl Ctr Sci Res, Ctr Nat Prod, Dept Pharmacol, Histol Lab, Havana, Cuba Natl Ctr Sci Res Havana Cuba , Dept Pharmacol, Histol Lab, Havana, Cuba
Titolo Testata:
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
fascicolo: 1, volume: 26, anno: 2000,
pagine: 13 - 17
SICI:
0378-6501(2000)26:1<13:CSODVS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; INJURY; NEUTROPHILS; BEESWAX; MUCOSA; DRUGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Noa, M Natl Ctr Sci Res, Ctr Nat Prod, Dept Pharmacol, Histol Lab, 25 Ave & 158 St, Havana, Cuba Natl Ctr Sci Res 25 Ave & 158 St Havana Cuba 158 St, Havana, Cuba
Citazione:
M. Noa et al., "Comparative study of D-002 versus sulfasalazine on acetic acid-induced colitis in rats", DRUG EXP CL, 26(1), 2000, pp. 13-17

Abstract

D-002 is a natural mixture of higher aliphatic primary alcohols purified from beeswax and has experimentally proven mild antiinflammatory and effective antiulcer effects. it reduces leukotrienes in the exudate of carrageenan-induced pleurisy and has a protective effect on the preulcerative phase ofcarrageenan-induced colonic ulceration in the guinea pig. This study was conducted to compare the effect of D-002 and sulfasalazine on acetic acid-induced colitis in rats administered at 1, 5.25 and 700 mg kg(-1), 24 h before colitis induction, Significant reductions in wet weight, macroscopic injury: polymorphonuclear infiltration and wail thickness were observed in the colonic mucosa of D-002 and sulfasalazine-treated animals compared with controls, except at the dose of I mg kg(-1), ii was concluded that the effectsof D-002 and sulfasalazine were comparable in this experimental model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:18:10