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Titolo:
Mobilization of peripheral blood stem cells by granulocyte-colony stimulating factors: Comparison of a standard dose of glycosylated and mutated granulocyte-colony stimulating factor in non-Hodgkin's lymphoma patients following CHOP therapy
Autore:
Takemoto, Y; Wada, H; Takatsuka, H; Okamoto, T; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
fascicolo: 1, volume: 26, anno: 2000,
pagine: 1 - 5
SICI:
0378-6501(2000)26:1<1:MOPBSC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD34(+) CELLS; G-CSF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Takemoto, Y Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawacho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawacho Nishinomiya Hyogo Japan 6638501
Citazione:
Y. Takemoto et al., "Mobilization of peripheral blood stem cells by granulocyte-colony stimulating factors: Comparison of a standard dose of glycosylated and mutated granulocyte-colony stimulating factor in non-Hodgkin's lymphoma patients following CHOP therapy", DRUG EXP CL, 26(1), 2000, pp. 1-5

Abstract

The effects of granulocyte-colony stimulating factor (G-CSF) have been studied in several clinical settings, G-CSFs are widely used to stimulate the production of granulocytes and are well known to mobilize peripheral blood stem cells (PBSCs). However; very few studies have examined differences among G-CSFs. The aim of this study was to compare the mobilization of PBSCs induced by a standard dose of two G-CSFs following biweekly cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) therapy: Using a standard dose of G-CSF; we conducted a randomized, crossover trial that compared theefficacy of two kinds of G-CSFS glycosylated [lenograstim (2 mu g/kg)] andmutated [nartograstim (1 mu g/kg)], on PBSC mobilization in 10 patients with non-Hodgkin's lymphoma after biweekly CHOP chemotherapy! Lenograstim (2 mu g/kg) was more effective in shortening the duration of neutropenia than nartograstim (1 mu g/kg) (3.8 days vs. 5.0 days, p < 0.05, the number of days for the neutrophil count to reach 5 x 10(9)/l from nadir). The number ofCD34+ cells and granulocyte-macrophage colony forming units (GM-CFU) was higher for lenograstim but no statistically significant difference between the two groups was found Glycosylated G-CSF is more effective than mutated G-CSF in shortening the duration of neutropenia. As for the mobilization of CD34+ cells and the number of CFU-GM, there was a tendency to increase in the lenograstim group but no statistically significant differences were found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 20:59:19