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Titolo:
Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa
Autore:
Ichikawa, T; Ishihara, K; Hayashida, H; Hiruma, H; Saigenji, K; Hotta, K;
Indirizzi:
Kitasato Univ, Sch Med, Dept Biochem, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan Kitasato Univ, Sch Med, Dept Physiol, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan Kitasato Univ, Sch Allied Hlth Sci, Dept Biochem, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288555 , Kanagawa 2288555, Japan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 3, volume: 45, anno: 2000,
pagine: 606 - 613
SICI:
0163-2116(200003)45:3<606:EOESAN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOSODIUM SALT TA-2711; HELICOBACTER-PYLORI; ANTIULCER AGENT; MONOCLONAL-ANTIBODIES; CARBOHYDRATE MOIETY; HYPERTONIC NACL; NITRIC-OXIDE; SECRETION; STOMACH; MUCUS;
Keywords:
ecabet sodium; rat; antrum; gastric mucin biosynthesis; prostaglandin E-2; monoclonal antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ichikawa, T Kitasato Univ, Sch Med, Dept Biochem, 1-15-1 Kitasato, Sagamihara, Kanagawa 2288555, Japan Kitasato Univ 1-15-1 Kitasato Sagamihara Kanagawa Japan 2288555
Citazione:
T. Ichikawa et al., "Effects of ecabet sodium, a novel gastroprotective agent, on mucin metabolism in rat gastric mucosa", DIG DIS SCI, 45(3), 2000, pp. 606-613

Abstract

The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [H-3]glucosamine incorporation into antral mucin as well as into corpus mucin during five successive hours of organ culture. In contrast, mucin biosynthesis in either antrum or corpus was not susceptible to the additionof ecabet to the culture medium. Ecabet-induced stimulation of prostaglandin E-2 production in the antrum was essentially the same as that seen in the corpus. In antrum treated with 100 mg/kg ecabet, immunoreactivity with three distinct anti-mucin monoclonal antibodies was found not only in the specific mucus-producing cells, but also in the secreted mucus present at the surface gel layer. These results suggest that ecabet enhances the mucin metabolism, and this stimulation occurs in both the corpus and antrum, suggesting that ecabet might be a useful tool for the further clarification of theregulatory mechanism of antral mucin synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:33:28