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Titolo:
Visceral adiposity and risk of type 2 diabetes - A prospective study amongJapanese Americans
Autore:
Boyko, EJ; Fujimoto, WY; Leonetti, DL; Newell-Morris, L;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Anthropol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Anthropol, Seattle, WA 98195 USA
Titolo Testata:
DIABETES CARE
fascicolo: 4, volume: 23, anno: 2000,
pagine: 465 - 471
SICI:
0149-5992(200004)23:4<465:VAAROT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; BODY-FAT DISTRIBUTION; FASTING PLASMA-INSULIN; ANTHROPOMETRIC MEASUREMENTS; ABDOMINAL OBESITY; COMPUTED-TOMOGRAPHY; TISSUE DISTRIBUTION; MASS INDEX; FOLLOW-UP; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Boyko, EJ Vet Affairs Puget Sound, Epidemiol Res & Informat Ctr, 1660 S Columbian Way,S111GIMC, Seattle, WA 98108 USA Vet Affairs Puget Sound 1660 S Columbian Way,S111GIMC Seattle WA USA 98108
Citazione:
E.J. Boyko et al., "Visceral adiposity and risk of type 2 diabetes - A prospective study amongJapanese Americans", DIABET CARE, 23(4), 2000, pp. 465-471

Abstract

OBJECTIVE - We conducted a prospective study among Japanese Americans of diabetes incidence in relation to visceral and regional adiposity, fasting insulin and C-peptide, and a measure of insulin secretion, because little prospective data exist on these associations. RESEARCH DESIGN AND METHODS - Baseline variables included plasma glucose, C-peptide, and insulin measured after an overnight fast and 30 and 120 min after a 75-g oral glucose tolerance test; abdominal, thoracic, and thigh fat areas by computed tomography (CT); BMI (kg/m(2)); and insulin secretion (incremental insulin response [IIR]). RESULTS - Study subjects included 290 second-generation (nisei) and 230 third-generation (sansei) Japanese Americans without diabetes, of whom 65 and13, respectively, developed diabetes. Among nisei, significant predictors of diabetes risk for a 1 SD increase in continuous variables included intra-abdominal fat area (IAFA) (odds ratio, 95% CI) (1.6, 1.1-2.3), fasting plasma C-peptide (1.4, 1.1-1.8), and the IIR (0.5, 0.3-0.9) after adjusting for age, sex, impaired glucose tolerance, family diabetes history, and CT-measured fat areas other than intraabdominal. Intra-abdominal fat area remained a significant predictor of diabetes incidence even after adjustment for BMI, total body fat area, and subcutaneous fat area, although no measure of regional or total adiposity was related to development of diabetes. Among sansei, all adiposity measures were related to diabetes incidence, but, in adjusted models, only IAFA remained significantly associated with higher risk (2.7, 1.4-5.4, BMI-adjusted). CONCLUSIONS - Greater visceral adiposity precedes the development of type 2 diabetes in Japanese Americans and demonstrates an effect independent of fasting insulin, insulin secretion, glycemia, total and regional adiposity,and family history of diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:32:13