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Titolo:
Effects of trimetazidine on clinical symptoms and tolerance of exercise ofpatients with syndrome X: a preliminary study
Autore:
Rogacka, D; Guzik, P; Wykretowicz, A; Rzezniczak, J; Dziarmaga, M; Wysocki, H;
Indirizzi:
Univ Sch Med Sci, Dept Internal Med, Div Cardiol Intens Therapy, PL-60355 Poznan, Poland Univ Sch Med Sci Poznan Poland PL-60355 Therapy, PL-60355 Poznan, Poland J Strus Hosp, Cardiosurg Dept, Hemodynam Lab, Poznan, Poland J Strus HospPoznan Poland rdiosurg Dept, Hemodynam Lab, Poznan, Poland Reg Cardiopulm Hosp, Kowanowko, Poland Reg Cardiopulm Hosp Kowanowko Poland Cardiopulm Hosp, Kowanowko, Poland
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 2, volume: 11, anno: 2000,
pagine: 171 - 177
SICI:
0954-6928(200003)11:2<171:EOTOCS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL CORONARY-ARTERIES; LEFT-VENTRICULAR FUNCTION; CHEST PAIN; ANGINA-PECTORIS; MYOCARDIAL PERFUSION; FLOW RESERVE; MICROVASCULAR ANGINA; VARIANT ANGINA; ANGIOGRAMS; ADENOSINE;
Keywords:
syndrome X; exercise treadmill test; trimetazidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Wysocki, H Univ Sch Med Sci, Dept Internal Med, Div Cardiol Intens Therapy, Przybyszewskiego 49, PL-60355 Poznan, Poland Univ Sch Med Sci Przybyszewskiego 49 Poznan Poland PL-60355 nd
Citazione:
D. Rogacka et al., "Effects of trimetazidine on clinical symptoms and tolerance of exercise ofpatients with syndrome X: a preliminary study", CORON ART D, 11(2), 2000, pp. 171-177

Abstract

Background Trimetazidine diminishes angina and improves tolerance of exercise of patients with ischemic heart disease, and has no influence on blood pressure and heart rate. Objective To determine the effect of trimetazidine on angina symptoms and exercise tolerance in patients with syndrome X. Methods We investigated the effect of trimetazidine on the clinical symptoms and tolerance of exercise of 34 patients (20 women and 14 men, aged 32 -60 years) with syndrome X (angina pectoris, positive result of exercise test, and normal coronary angiogram). The exercise test was performed before initiation of oral administration of trimetazidine therapy (20 mg three times a day) and 1 and 6 months thereafter. Results We obtained negative results of exercise treadmill tests for four patients (11.76%) after 1 month and five patients (14.71%) after 6 months of trimetazidine treatment. There was also a decrease in the incidence of effort angina after 6 months of treatment (26 patients or 76.47% before treatment versus 13 patients or 38.23% after 6 months of treatment). The drug had no significant influence on the heart rate and blood pressure. The duration for which patients could exercise was significantly prolonged by 1 month(652.9 +/- 206.2 versus 563.4 +/- 190.4 s, P = 0.0047) and 6 months (650.3+/- 207.8 s, P = 0.0094) of treatment with trimetazidine. Conclusion Treatment with trimetazidine decreases signs of angina during exercise and improves tolerance of exercise of patients with syndrome X. Coronary Artery Dis 11:171-177 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:30:42