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Titolo:
Exercise and thrombosis
Autore:
Koenig, W; Ernst, E;
Indirizzi:
Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89081 Ulm, Germany Univ Ulm Ulm Germany D-89081 nternal Med Cardiol 2, D-89081 Ulm, Germany Univ Exeter, Postgrad Med Sch, Dept Complementary Med, Exeter, Devon, England Univ Exeter Exeter Devon England mplementary Med, Exeter, Devon, England
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 2, volume: 11, anno: 2000,
pagine: 123 - 127
SICI:
0954-6928(200003)11:2<123:EAT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; PLASMA-FIBRINOGEN CONCENTRATION; CORONARY-ARTERY DISEASE; TIME PHYSICAL-ACTIVITY; MYOCARDIAL-INFARCTION; RISK-FACTORS; PLASMINOGEN-ACTIVATOR; FIBRINOLYTIC-ACTIVITY; PLATELET ACTIVATION; AEROBIC EXERCISE;
Keywords:
exercise; physical activity; fibrinogen; factor VII; PAI-1; t-PA; platelet hyper-aggregation; thrombin; activation markers; intervention studies; cross-sectional studies;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Koenig, W Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, Robert Koch Str 8, D-89081Ulm, Germany Univ Ulm Robert Koch Str 8 Ulm Germany D-89081 9081Ulm, Germany
Citazione:
W. Koenig e E. Ernst, "Exercise and thrombosis", CORON ART D, 11(2), 2000, pp. 123-127

Abstract

Long-term moderate or strenuous physical activity is associated with a considerable reduction in cardiovascular morbidity and mortality. This articlereviews the evidence to suggest that part of the effect is mediated through the effects on thrombogenic factors. Fibrinogen has been convincingly shown to be an independent cardiovascular risk factor. Other hemostatic and fibrinolytic parameters that are predictive of coronary events include factorVII, platelet hyperreactivity, plasminogen activator inhibitor-1, and tissue-plasminogen activator. The effects of exercise on fibrinogen have been studied intensively One randomized, controlled trial, two other interventionstudies and a large number of population-based cross-sectional studies have consistently found an inverse relationship between various measures of sport activity or leisure activity and plasma levels of fibrinogen. The magnitude of the effect might be associated with a sizeable reduction in major coronary events. Relatively few data are available on endurance exercise andmarkers of the fibrinolytic system. Acute exercise leads to a transient activation of the coagulation system, which is accompanied by an increase in the fibrinolytic capacity in healthy subjects. However, patients with ischemic heart disease, who cannot increase their fibrinolytic potential, may beat considerable risk for acute ischemic events if they are exposed to unaccustomed strenuous physical exertion. It is concluded that physical activity has profound effects on thrombogenic factors and that these mechanisms could contribute to its beneficial cardiovascular effects. Coronary Artery Dis 1 1:123-127 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:05:30