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Titolo:
Congenic rats for hypertension: How useful are they for the hunting of hypertension genes?
Autore:
Nabika, T; Kobayashi, Y; Yamori, Y;
Indirizzi:
Shimane Med Univ, Dept Lab Med, Izumo, Shimane 693, Japan Shimane Med Univ Izumo Shimane Japan 693 b Med, Izumo, Shimane 693, Japan Shimane Med Univ, Cent Res Labs, Izumo, Shimane 693, Japan Shimane Med Univ Izumo Shimane Japan 693 Labs, Izumo, Shimane 693, Japan Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto, Japan Kyoto Univ Kyoto Japan Grad Sch Human & Environm Studies, Kyoto, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 4, volume: 27, anno: 2000,
pagine: 251 - 256
SICI:
0305-1870(200004)27:4<251:CRFHHU>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; HIGH BLOOD-PRESSURE; SALT-SENSITIVE RATS; Y-CHROMOSOME; RENIN GENE; SEX SPECIFICITY; CARDIAC MASS; LINKAGE MAP; DAHL RATS; STRAINS;
Keywords:
congenic rats; Dahl salt-sensitive rats; essential hypertension; genetics; multifactorial disease; quantitative trait loci; spontaneously hypertensive rats;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Nabika, T Shimane Med Univ, Dept Lab Med, Izumo, Shimane 693, Japan Shimane Med Univ Izumo Shimane Japan 693 mo, Shimane 693, Japan
Citazione:
T. Nabika et al., "Congenic rats for hypertension: How useful are they for the hunting of hypertension genes?", CLIN EXP PH, 27(4), 2000, pp. 251-256

Abstract

1. Linkage studies have revealed quantitative trait loci (QTL) for blood pressure in the rat genome using genetic hypertensive rat models. To identify the genes responsible for hypertension, the construction of congenic ratsis essential.2. To date, several congenic strains have been obtained from spontaneouslyhypertensive or Dahl salt-sensitive rats. The results of these studies should be interpreted according to whether the rats carry the whole QTL regionor not.3. After establishing congenic strains, three strategies are possible: (i)an orthodox positional cloning in which, using sub-congenic strains, the QTL region is cut down to smaller fragments suitable for physical mapping; (ii) a positional candidate strategy in which candidate genes in the QTL regions are studied; or (iii) physiological studies in which intermediate phenotypes directly associated with the hypertension gene are explored. Severalother experimental strategies are also available using congenic strains asnew animal models for hypertension.4. To make the most of advances in DNA technology, the precise evaluation of the phenotypic difference between congenic strains carrying different QTL or between a congenic and parental strain is critical.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:46:44