Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagus
Autore:
Koyanagi, K; Ozawa, S; Ando, N; Mukai, M; Kitagawa, Y; Ueda, M; Kitajima, M;
Indirizzi:
Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 pt Surg, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ, Sch Med, Div Diagnost Pathol, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Div Diagnost Pathol, Tokyo 1608582, Japan
Titolo Testata:
CANCER
fascicolo: 7, volume: 88, anno: 2000,
pagine: 1524 - 1529
SICI:
0008-543X(20000401)88:7<1524:TAAAIO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; HUMAN FIBROBLASTS; P53 GENE; CANCER; MUTATION; TUMORS;
Keywords:
telomerase; immortalization; iodine-nonreactive lesion; esophageal squamous cell carcinoma; carcinoma in situ; dysplasia; carcinogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, M Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, 35 Shinanomachi, Tokyo1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 okyo 1608582, Japan
Citazione:
K. Koyanagi et al., "Telomerase activity as an indicator of malignant potential in iodine-nonreactive lesions of the esophagus", CANCER, 88(7), 2000, pp. 1524-1529

Abstract

BACKGROUND. Iodine-nonreactive lesions of esophageal epithelium often are associated with dysplasia and carcinoma. The authors examined the usefulness of telomerase activity as an indicator for esophageal carcinogenesis in such lesions. METHODS, Telomerase activity was measured using the telomeric repeat amplification protocol assay in 18 samples of iodine-nonreactive lesions apart from the primary tumor in surgically resected specimens obtained from patients with esophageal squamous cell carcinoma (ESCC) and 55 endoscopic punch biopsies of iodine-nonreactive lesions obtained from 25 patients with ESCC and 30 patients who had undergone endoscopic examination for other reasons. RESULTS. Ten of 18 iodine-nonreactive samples (56%) obtained from surgically resected specimens showed telomerase activity. In all ten telomerase positive samples, carcinoma in situ (CIS) was observed in iodine-nonreactive mucosa by light microscopy. In eight telomerase negative samples, no tumor tissue was observed in iodine-nonreactive lesions. In a parallel study, telomerase activity was detected in 28 of 55 endoscopic punch biopsy specimens (51%). CIS was observed in 25 of 28 iodine-nonreactive lesions with positive telomerase activity (89%), and tumor tissue was not observed in the other3 samples (11%), which included 2 cases of severe dysplasia and 1 case of moderate dysplasia. No tumor tissue was observed in any of the 27 telomerase negative samples. CONCLUSIONS. Positive and negative telomerase activity was found to be correlated with the presence and absence, respectively, of immortalized tumor cells in iodine-nonreactive lesions. The measurement of telomerase activityin iodine-nonreactive lesions independently contributes to the selection of an appropriate therapeutic strategy. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:28:47