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Titolo:
Biomechanical and histological evaluation of hydrogel implants in articular cartilage
Autore:
Malmonge, SM; Zavaglia, CAC; Belangero, WD;
Indirizzi:
Univ Estadual Campinas, Ctr Tecnol, Lab Engn Biomecan, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil Univ Estadual Campinas, Fac Engn Mecan, Dept Mat Engn, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil Univ Estadual Campinas, Fac Med, Dept Ortopedia & Traumatol, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCpinas, SP, Brazil
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 3, volume: 33, anno: 2000,
pagine: 307 - 312
SICI:
0100-879X(200003)33:3<307:BAHEOH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPHASIC INDENTATION; POLYMER SYSTEM; REGENERATION; GRAFTS;
Keywords:
biomaterial; cartilage repair; hydrogel; biomechanical evaluation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Malmonge, SM Univ Estadual Campinas, Ctr Tecnol, Lab Engn Biomecan, Caixa Postal 6131, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas Caixa Postal 6131 Campinas SP Brazil BR-13083970 BC
Citazione:
S.M. Malmonge et al., "Biomechanical and histological evaluation of hydrogel implants in articular cartilage", BRAZ J MED, 33(3), 2000, pp. 307-312

Abstract

We evaluated the mechanical behavior of the repaired surfaces of defectivearticular cartilage in the intercondylar region of the rat femur after a hydrogel graft implant. The results were compared to those for the adjacent normal articular cartilage and for control surfaces where the defects remained empty. Hydrogel synthesized by blending poly(2-hydroxyethyl methacrylate) and poly(methyl methacrylate-co-acrylic acid) was implanted in male Wistar rats. The animals were divided into five groups with postoperative follow-up periods of 3, 5, 8, 12 and 16 weeks. Indentation tests were performed on the neoformed surfaces in the knee joint (with or without a hydrogel implant) and on adjacent articular cartilage in order to assess the mechanicalproperties of the newly formed surface. Kruskal-Wallis analysis indicated that the mechanical behavior of the neoformed surfaces was significantly different from that of normal cartilage. Histological analysis of the repaired defects showed that the hydrogel implant filled the defect with no signs of inflammation as it was well anchored to the surrounding tissues, resulting in a newly formed articular surface. In the case of empty control defects, osseous tissue grew inside the defects and fibrous tissue formed on the articular surface of the defects. The repaired surface of the hydrogel implant was more compliant than normal articular cartilage throughout the 16 weeks following the operation, whereas the fibrous tissue that formed postoperatively over the empty defect was stiffer than normal articular cartilage after 5 weeks. This stiffness started to decrease 16 weeks after the operation, probably due to tissue degeneration. Thus, from the biomechanical and histological point of view, the hydrogel implant improved the articular surface repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:28:36