Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Schizophrenia and the mechanisms of conscious integration
Autore:
Tononi, G; Edelman, GM;
Indirizzi:
Inst Neurosci, San Diego, CA 92121 USA Inst Neurosci San Diego CA USA 92121 st Neurosci, San Diego, CA 92121 USA
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 2-3, volume: 31, anno: 2000,
pagine: 391 - 400
SICI:
0165-0173(200003)31:2-3<391:SATMOC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
THALAMOCORTICAL SYSTEM; NEURAL DYNAMICS; MODEL; BRAIN; COMPLEXITY; PSYCHOSIS;
Keywords:
schizophrenia; imaging; PET; functional clustering; MEG; consciousness; re-entry; binocular rivalry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tononi, G Inst Neurosci, 10640 John J Hopkins Dr, San Diego, CA 92121 USA Inst Neurosci 10640 John J Hopkins Dr San Diego CA USA 92121 USA
Citazione:
G. Tononi e G.M. Edelman, "Schizophrenia and the mechanisms of conscious integration", BRAIN RES R, 31(2-3), 2000, pp. 391-400

Abstract

This article considers the possibility that defective interactions among distributed brain areas may underlie certain dysfunctions of conscious integration such as those seen in schizophrenia. Recent experimental evidence obtained using whole-head magnetoencephalography during binocular rivalry is first reviewed. The results outline a cortical network that underlies conscious integration in the normal brain. This network is not localized to a small part of the brain but it is distributed over frontal, parietal, temporal, and occipital areas. Large-scale simulations of the dynamics of thalamocortical integration are then examined. These studies indicate that several factors can affect the rapid integration of the activity of distributed thalamocortical regions and the resulting behavioral performance. These simulations show that an altered dynamics of corticothalamic and corticocortical re-entrant circuits can result from increased conduction delays, blockade of voltage-dependent connections, reduced synaptic density, and disruptions of the local connectivity within a single cortical area. It can also resultfrom alterations in the activity of diffuse ascending systems that lead todefective reinforcement of integrated activity patterns. Finally, the article briefly reviews theoretical measures of the integration of multiple brain areas, such as measures of functional clustering. These measures have been applied to PET data obtained from schizophrenic subjects and controls while performing cognitive tasks. The results show a change in the functionalinteractions among distributed brain areas in schizophrenics despite the absence of a change in activation patterns. The possibility is raised that disruption of re-entrant interactions among cortical areas may contribute tothe pathophysiology of schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:01:56