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Titolo:
The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies
Autore:
Laruelle, M;
Indirizzi:
Columbia Univ, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 2-3, volume: 31, anno: 2000,
pagine: 371 - 384
SICI:
0165-0173(200003)31:2-3<371:TROESI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; STRIATAL DOPAMINE RELEASE; RAT PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA; AMPHETAMINE-INDUCED SENSITIZATION; TIME-DEPENDENT SENSITIZATION; PARANOID PSYCHOTIC STATE; C-11 RACLOPRIDE BINDING; IBOTENIC ACID LESIONS; FREELY MOVING RATS;
Keywords:
schizophrenia; dopamine; D-2 receptors; SPECT; psychostimulants; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Laruelle, M Columbia Univ, New York State Psychiat Inst, Dept Psychiat, 1051 RiversideDr,Unit 42, New York, NY 10032 USA Columbia Univ 1051 RiversideDr,Unit 42 New York NY USA 10032
Citazione:
M. Laruelle, "The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies", BRAIN RES R, 31(2-3), 2000, pp. 371-384

Abstract

Long-term sensitization is a process whereby exposure to a given stimulus such as a drug or a stressor results in an enhanced response at subsequent exposures. Sensitization of mesolimbic dopamine systems has been postulatedby several authors to underlie the development of dopaminergic abnormalities associated with schizophrenia. In this review, core features of stimulant-induced sensitization of dopamine systems in rodents are briefly reviewed, as well as the behavioral and clinical evidence suggesting the relevance of this process to drug-induced psychosis and schizophrenia. Results of recent brain imaging studies relevant to the question of sensitization in schizophrenia are then discussed. These studies indicate that schizophrenia is associated with increased amphetamine-induced dopamine release. This exaggerated response was detected in patients experiencing an episode of clinicaldeterioration but not in clinically stable patients. Since increased stimulant-induced dopamine release is a hallmark of sensitization, these resultssupport the view that schizophrenia is associated with a process of endogenous sensitization. Based on the preclinical evidence that dopamine projection to the prefrontal cortex acts as a buffer that oppose the development of sensitization in subcortical dopamine projections, we propose that, in schizophrenia, neurodevelopmental abnormalities of prefrontal dopaminergic systems might result in a state of enhanced vulnerability to sensitization during late adolescence and early adulthood. It is also proposed that D-2 receptor blockade, if sustained, might allow for an extinction of this sensitization process, with possible re-emergence upon treatment discontinuation. A better understanding of the neurocircuitry associated with endogenous sensitization and its consequence in schizophrenia might be important for the development of better treatment and relapse prevention strategies. (C) 2000Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:56:20