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Titolo:
Neurobiological findings in early phase schizophrenia
Autore:
Copolov, D; Velakoulis, D; McGorry, P; Mallard, C; Yung, A; Rees, S; Jackson, G; Rehn, A; Brewer, W; Pantelis, C;
Indirizzi:
Mental Hlth Res Inst Victoria, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia NHMRC Network Brain Res Mental Disorders, Kings Cross, Australia NHMRC Network Brain Res Mental Disorders Kings Cross Australia ustralia Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Early Psychosis Prevent & Intervent Ctr, Melbourne, Vic, Australia Early Psychosis Prevent & Intervent Ctr Melbourne Vic Australia ustralia Univ Melbourne, Dept Anat, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia t Anat, Melbourne, Vic, Australia Univ Melbourne, Dept Cell Biol, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia l Biol, Melbourne, Vic, Australia Univ Melbourne, Austin & Repatriat Med Ctr, Brain Imaging Res Inst, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia s Inst, Melbourne, Vic, Australia Personal Assistance & Crisis Evaluat Clin, Melbourne, Vic, Australia Personal Assistance & Crisis Evaluat Clin Melbourne Vic Australia tralia
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 2-3, volume: 31, anno: 2000,
pagine: 157 - 165
SICI:
0165-0173(200003)31:2-3<157:NFIEPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; POSTTRAUMATIC-STRESS-DISORDER; TEMPORAL-LOBE EPILEPSY; HIPPOCAMPAL VOLUME REDUCTION; ANTIPSYCHOTIC-DRUGS; PSYCHOTIC-PATIENTS; DEXAMETHASONE SUPPRESSION; DIFFERENTIAL REGULATION; ULTRASTRUCTURAL-CHANGES; KALLMANNS-SYNDROME;
Keywords:
schizophrenia; hippocampus; first episode; high risk; placental insufficiency; uterine ligation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Copolov, D Mental Hlth Res Inst Victoria, 155 Oak St, Parkville, Vic 3052,Australia Mental Hlth Res Inst Victoria 155 Oak St Parkville Vic Australia3052
Citazione:
D. Copolov et al., "Neurobiological findings in early phase schizophrenia", BRAIN RES R, 31(2-3), 2000, pp. 157-165

Abstract

This paper summarises the available information on MRI-determined hippocampal morphometry in first-episode patients as an illustration of the value and interpretation of findings in the neurobiology of early phase schizophrenia. We report a thin slice (1.5 mm) study of 32 first episode and 39 high risk patients which demonstrated significantly smaller hippocampi (right - 9%, left - 11%) in first episode patients that were of a similar magnitude to those found in chronic patients (right - 10%, left - 11%) but non-significant volume reductions in high risk individuals, including the 15 subjectswho subsequently developed psychoses. Consideration is given to the implications of these findings, including the possible role of early and later neurodevelopmental influences. We present animal data showing that chronic placental insufficiency, as elicited by uterine artery ligation can give riseto substantial reduction (31%) in hippocampal volumes and reflect on otherpotentially relevant pathophysiological mechanisms, including those that may occur during the early phases of psychotic illnesses, including their prodromes. Greater attention needs to be paid to the study of early phase psychosis in order to obtain a clearer understanding of the nature and time course of neurobiological changes associated with it. Although there is a growing literature on first episode psychosis, there is a striking dearth of information on the neurobiology of the prodrome. (C) 2000 Elsevier Science, B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:35:16