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Titolo:
Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species
Autore:
Crow, TJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, POWIC, Oxford OX3 7JX, EnglandUniv Oxford Oxford England OX3 7JX chiat, POWIC, Oxford OX3 7JX, England
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 2-3, volume: 31, anno: 2000,
pagine: 118 - 129
SICI:
0165-0173(200003)31:2-3<118:SATPTH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELATIVE HAND SKILL; RIGHT-SHIFT THEORY; AGE-OF-ONSET; CEREBRAL ASYMMETRY; PLANUM TEMPORALE; SEXUAL SELECTION; X-CHROMOSOME; GRAY-MATTER; HANDEDNESS; PSYCHOSIS;
Keywords:
language; schizophrenia; evolution; Homo sapiens; X-Y homology; speciation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Crow, TJ Univ Oxford, Warneford Hosp, Dept Psychiat, POWIC, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX WIC, Oxford OX3 7JX, England
Citazione:
T.J. Crow, "Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species", BRAIN RES R, 31(2-3), 2000, pp. 118-129

Abstract

The central paradox of schizophrenia is that the condition, apparently genetic in origin, persists in spite of a substantial fecundity disadvantage. The hypothesis is proposed that the predisposition to schizophrenia is a component of Homo sapiens-specific variation associated with the capacity forlanguage. a genetic change (the 'speciation event', predicted to be related to the Xq21.3 to Yp chromosomal transposition that separates Homo sapiensfrom the great apes) allowed the hemispheres to develop with a 'cerebral torque', reflected particularly in association cortex, from right frontal toleft occipital. Variations in the dimension of lateralization are associated with differences in the rate at which verbal and non-verbal ability develops. The nuclear symptoms of schizophrenia can he understood as a failure to establish dominance for a key component - the phonological sequence - oflanguage in one hemisphere, with consequent disruption of the mechanism of'indexicality' that allows the speaker to distinguish his thoughts from the speech output that he generates and the speech input that he receives anddecodes Gum others. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:27:29