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Titolo:
Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation
Autore:
Tsukada, N; Akiba, H; Kobata, T; Aizawa, Y; Yagita, H; Okumura, K;
Indirizzi:
Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 unol, Mibu, Tochigi 3210293, Japan Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Immunol, Tokyo 113, Japan Niigata Univ, Sch Med, Dept Internal Med 1, Niigata, Japan Niigata Univ Niigata Japan Sch Med, Dept Internal Med 1, Niigata, Japan JST, CREST, Tokyo, Japan JST Tokyo JapanJST, CREST, Tokyo, Japan
Titolo Testata:
BLOOD
fascicolo: 7, volume: 95, anno: 2000,
pagine: 2434 - 2439
SICI:
0006-4971(20000401)95:7<2434:BOC(IA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL DEPLETION; TUMOR-NECROSIS-FACTOR; OX40 LIGAND; ENDOTHELIAL-CELLS; FAS LIGAND; ACUTE GVHD; ANTIBODY; MICE; RECEPTOR; LEUKEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kobata, T Dokkyo Univ, Sch Med, Inst Med Sci, Div Immunol, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan Dokkyo Univ 880 Kitakobayashi Mibu TochigiJapan 3210293 , Japan
Citazione:
N. Tsukada et al., "Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation", BLOOD, 95(7), 2000, pp. 2434-2439

Abstract

Expression of CD134 (OX40) on activated CD4(+) T cells has been observed in acute graft-versus-host disease (GVHD) after human and rat allogeneic bone marrow transplantation (BMT). We investigated the role of interaction between CD134 and CD134 ligand (CD134L) in a murine model of acute GVHD by using a newly established monoclonal antibody (mAb) against murine CD134L, Acute GVHD was induced by transfer of bone marrow cells and spleen cells into lethally irradiated recipients in a parent (C57BL/6) to first filial generation (C57BL/6 crossed with DBA/2) BMT, Administration of anti-CD134L mAb significantly reduced the lethality of acute GVHD and other manifestations ofthe disease, such as loss of body weight, hunched posture, diarrhea, and patchy alopecia. The survival rate 80 days after BMT in mice treated with the mAb was about 70%, whereas all mice treated with control antibodies died within 43 days. Histologic examinations revealed that inflammatory changes in target organs such as the liver, gut, and skin were also ameliorated in mice treated with the mAb compared with control mice. An in vitro assay of T-cell proliferation showed a marked hyporesponsiveness to host alloantigenIn samples from mice treated with anti-CD134L mAb, In addition, low levelsof interferon gamma and transiently elevated levels of interleukin 4 and IgE in serum samples were found in mice treated with anti-CD134L mAb, These results suggest that CD134-CD134L interactions have an important role in the pathogenesis of acute GVHD, (Blood, 2000;95:2434-2439) (C) 2000 by The American Society of Hematology.

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Documento generato il 05/07/20 alle ore 13:28:40