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Titolo:
Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15
Autore:
Verma, S; Hiby, SE; Loke, YW; King, A;
Indirizzi:
Univ Cambridge, Dept Pathol, Res Grp Human Reprod Immunobiol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP iol, Cambridge CB2 1QP, England
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 4, volume: 62, anno: 2000,
pagine: 959 - 968
SICI:
0006-3363(200004)62:4<959:HDNKCE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; HUMAN EXTRAVILLOUS TROPHOBLAST; POLYMERASE CHAIN-REACTION; EARLY-PREGNANCY DECIDUA; C-KIT LIGAND; HUMAN-ENDOMETRIUM; NK CELLS; MENSTRUAL-CYCLE; IL-2 RECEPTOR; PROLIFERATIVE ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: King, A Univ Cambridge, Dept Pathol, Res Grp Human Reprod Immunobiol, Tennis CourtRd, Cambridge CB2 1QP, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP England
Citazione:
S. Verma et al., "Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15", BIOL REPROD, 62(4), 2000, pp. 959-968

Abstract

The natural killer (NK) cells that are present in the uterine mucosa (decidua) during early pregnancy have a distinctive phenotype, CD56(bright) CD16(-). These cells have previously been shown to proliferate and be activatedby interleukin (IL)-2. However, IL-2 is absent from the decidua and placenta, and we have therefore investigated whether IL-15 is present in the uterus and can act on decidual NK cells. Both IL-15 mRNA and protein were foundin a variety of cells but particularly in decidual macrophages. IL-15 induced a proliferative response in decidual NK cells that was blocked by anti-IL-15 and was augmented by stem cell factor. The cytolytic activity of decidual NK cells against K562 was augmented. Interestingly, in contrast to IL-2, although activation with IL-15 resulted in some killing of JEG-3 choriocarcinoma cells, normal trophoblast cells remained resistant to lysis. Thesefindings suggest that IL-15 is a candidate cytokine responsible for NK cell proliferation in vivo in the progesterone-dominated secretory endometriumand early decidua.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 02:29:19