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Titolo:
Alteration in cardiomyocyte mechanics by suboptimal levels of extracellular magnesium
Autore:
Nair, P; Nair, RR;
Indirizzi:
Sree Chitra Tirunal Inst Med Sci & Technol, Div Cellular & Mol Cardiol, Trivandrum 695011, Kerala, India Sree Chitra Tirunal Inst Med Sci & Technol Trivandrum Kerala India 695011
Titolo Testata:
BIOLOGICAL TRACE ELEMENT RESEARCH
fascicolo: 3, volume: 73, anno: 2000,
pagine: 193 - 200
SICI:
0163-4984(200003)73:3<193:AICMBS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC MYOCYTES; CALCIUM; CONSEQUENCES; DEFICIENCY; RAT;
Keywords:
adult rat; cardiac myocytes; cardiomyocyte mechanics; extracellular magnesium; magnesium deficiency; contractile amplitude; contraction velocity; relaxation velocity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nair, RR Sree Chitra Tirunal Inst Med Sci & Technol, Div Cellular & Mol Cardiol, Trivandrum 695011, Kerala, India Sree Chitra Tirunal Inst Med Sci & Technol Trivandrum Kerala India 695011
Citazione:
P. Nair e R.R. Nair, "Alteration in cardiomyocyte mechanics by suboptimal levels of extracellular magnesium", BIOL TR EL, 73(3), 2000, pp. 193-200

Abstract

The beneficial effects of magnesium supplementation in pathological situations is well known, but the myocardial response to a nominal decrease in the level of magnesium has received relatively little attention. Hypomagnesemia can occur as chronic or acute manifestation of physiological changes, pathological conditions, or pharmacological interventions. Experimental interest was focused on the mechanical changes in adult rat heart myocytes following variation in extracellular Mg2+. Isolated cells were exposed to different levels of extracellular Mg2+ and the amplitude and rate of contraction were measured as a function of change in cell length using a video-based edge-detection system. Investigations have revealed that variation in the level of Mg2+ within physiological limits leads to mechanical changes. A decrease in the level of extracellular Mg2+ was accompanied by a significant increase in contractile amplitude and decrease in the velocities of contraction and relaxation. The contractile amplitude measured as percentage shortening were 3.08 +/- 0.19%, 4.62 +/- 0.19% and 6.9 +/- 0.40%, respectively, on exposure to 1.8, 0.8, and 0.48 mM Mg, and the corresponding velocities of contraction and relaxation normalized to amplitude were 0.54 +/- 0.02, 0.40 /- 0.03, 0.31 +/- 0.03 and 0.47 +/- 0.02, 0.35 +/- 0.02, 0.24 +/- 0.02. The variations in contractile parameters associated with the change in the level of Mg were statistically significant (p < 0.01). Variation in the contractile properties associated with change in extracellular Mg2+ may be effected by alteration in Ca2+ transients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:03:17