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Titolo:
Impaired prepulse inhibition of acoustic startle in schizophrenia
Autore:
Parwani, A; Duncan, EJ; Bartlett, E; Madonick, SH; Efferen, TR; Rajan, R; Sanfilipo, M; Chappell, PB; Chakravorty, S; Gonzenbach, S; Ko, GN; Rotrosen, JP;
Indirizzi:
New York Vet Affairs Med Ctr, Psychiat Serv, New York, NY 10010 USA New York Vet Affairs Med Ctr New York NY USA 10010 New York, NY 10010 USA Pfizer Inc, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340Pfizer Inc, Groton, CT 06340 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 47, anno: 2000,
pagine: 662 - 669
SICI:
0006-3223(20000401)47:7<662:IPIOAS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEAK PRE-STIMULATION; ANIMAL-MODEL; REFLEX; SENSORIMOTOR; HABITUATION; PSYCHOSIS; MODULATION; ATTENTION; NORMALS; BLINK;
Keywords:
prepulse inhibition; schizophrenia; acoustic startle; sensorimotor gating; habituation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, EJ New York Vet Affairs Med Ctr, Psychiat Serv, 116A,423 East 23rdSt, New York, NY 10010 USA New York Vet Affairs Med Ctr 116A,423 East 23rdSt New York NY USA 10010
Citazione:
A. Parwani et al., "Impaired prepulse inhibition of acoustic startle in schizophrenia", BIOL PSYCHI, 47(7), 2000, pp. 662-669

Abstract

Background: Schizophrenics show deficits in sensorimotor gating, as measured by prepulse inhibition of acoustic startle (PPI). The goal of this investigation is to further characterize, PPI and habituation deficits in schizophrenia, and to examine whether differing subgroups of schizophrenics wouldshow conrparable PPI deficits. Methods: PPI was measured in 24 male schizophrenic subjects (9 acutely decompensated inpatients and 15 stable outpatients) and in 20 age-marched normal control subjects, Schizophrenic subjects were rated for positive and negative symptoms at the time of testing,Results: Schizophrenic subjects showed deficits in prepulse inhibition andhabituation as compared to normal subjects. Similar latency facilitation was produced by the prepulse ill both groups. Acutely decompensated inpatients and stable outpatients did not differ in percent PPI. PPI did not con-elate with severity of positive or negative symptoms. Conclusions: These results suggest that schizophrenic subjects have impaired central inhibitory mechanisms as measured by PPI, and support the hypothesis that periods of relative clinical remission are not accompanied by normalization, of sensorimotor gating. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:39:46