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Titolo:
A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity
Autore:
Heinz, A; Jones, DW; Mazzanti, C; Goldman, D; Ragan, P; Hommer, D; Linnoila, M; Weinberger, DR;
Indirizzi:
NIMH, Clin Brain Disorders Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 mural Res Program, NIH, Bethesda, MD 20892 USA NIAAA, Clin Studies Lab, Intramural Res Program, Bethesda, MD 20892 USA NIAAA Bethesda MD USA 20892 ntramural Res Program, Bethesda, MD 20892 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 47, anno: 2000,
pagine: 643 - 649
SICI:
0006-3223(20000401)47:7<643:ARBSTG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-HUMAN SUBJECTS; MESSENGER-RNA LEVELS; BETA-CIT BINDING; HUMAN BRAIN; IN-VIVO; DOPAMINE TRANSPORTERS; NONHUMAN-PRIMATES; COCAINE; AVAILABILITY; SENSITIVITY;
Keywords:
alcoholism; gene expression; SLC6A4; serotonin transporters; SPECT; beta-CIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberger, DR NIMH, Clin Brain Disorders Branch, Intramural Res Program, NIH, 10 Ctr Dr,4S-235,MSC 1379, Bethesda, MD 20892 USA NIMH 10 Ctr Dr,4S-235,MSC 1379 Bethesda MD USA 20892 92 USA
Citazione:
A. Heinz et al., "A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity", BIOL PSYCHI, 47(7), 2000, pp. 643-649

Abstract

Background: Genetic variation of the promoter for the serotonin transporter (5-HTT) gene has been associated with its functional capacity, In vitro, carriers of a short allele (s-carriers) of the 5-HTT promoter display significant reduction? in 5-HTT capacity. Dysfunction of 5-HTT has been observedin alcoholic individuals. We assessed whether the allelic constitution of the 5-HTT gene is associated with reduced serotonin transporter availability among alcoholic individuals,Methods: We genotyped the 5-HTT promoter region and measured the availability of serotonin transporter protein with [I-123]beta-CIT SPECT in the raphe area in 14 abstinent male alcoholic subjects and 8 age-matched control subjects of European American descent. Results: Among control subjects, the ratio of in vivo 5-HTT availability for 11-homozygous individuals relative to s-carriers was comparable to serotonin uptake ratios measured in vitro. There was a significant interaction of diagnosis and 5-HTT promoter genotype on 5-HTT availability (p < .01), Among controls, 11-homozygous individuals displayed a significant increase ascompared with s-carriers. The availability of raphe 5-HTT was significantly reduced in 11-homozygous alcoholic individuals and was negatively correlated with their amount of alcohol consumption. Among s-carriers, 5-HTT availability did nor differ significantly between control and alcoholic subjects. Conclusions: Our preliminary findings suggest an association between 5-HTTallelic constitution and in vivo measurements of human serotonin transporter availability, and a potentially selective susceptibility of 11-homozygous individuals to the neurotoxic effects of chronic excessive alcohol consumption.

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Documento generato il 26/09/20 alle ore 07:14:44