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Titolo:
Sleep electroencephalographic coherence abnormalities in individuals at high risk for depression: A pilot study
Autore:
Fulton, MK; Armitage, R; Rush, AJ;
Indirizzi:
Univ Texas, Dept Psychiat, Sleep Study Unit, SW Med Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 udy Unit, SW Med Ctr, Dallas, TX 75235 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 47, anno: 2000,
pagine: 618 - 625
SICI:
0006-3223(20000401)47:7<618:SECAII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIGITAL PERIOD ANALYSIS; PSYCHIATRIC-DISORDERS; MAJOR DEPRESSION; REM-SLEEP; UNIPOLAR DEPRESSION; EEG; ADOLESCENTS; CHILDREN; ILLNESS; PARAMETERS;
Keywords:
sleep EEG coherence; depression; high-risk individuals; vulnerability; period amplitude analysis; power spectral analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Armitage, R Univ Texas, Dept Psychiat, Sleep Study Unit, SW Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
M.K. Fulton et al., "Sleep electroencephalographic coherence abnormalities in individuals at high risk for depression: A pilot study", BIOL PSYCHI, 47(7), 2000, pp. 618-625

Abstract

Background: Sleep electroencephalographic (EEG) studied of individuals with major depressive disorder have identified several microarchitectural features associated with the illness. These abnormalities are also found in clinically remitted individuals, raising the question of whether they are vulnerability markers of depression. This study evaluated the sleep EEG in high-risk individuals to see if abnormalities are present in the sleep EEG prior to the onset of illness. Methods: A total of 26 subjects (13 males and 13 females) were recruited for study on rite basis of 1) having a parent or. grandparent treated for major depressive or bipolar affective disorder and 2) having no history, of personal psychiatric illness. Polysomnographic data were collected and compared with gender and age-matched healthy control subjects with no personal or family history of psychiatric illness. The primary outcome measures were interhemispheric and intrahemispheric coherence. Results: Period analysis of the sleep EEG showed that beta-delta coherencewas lower bilaterally in male highrisk subjects, Right-hemispheric theta-delta coherence was also lower in male high-risk subjects, with female high-risk subjects evidencing lower beta coherence. Conclusions: Sleep-EEG abnormalities associated with major depressive disorder are present in never mentally ill individuals at high risk for the illness. These markers may be useful in the prediction of illness and iii family genetic studies of mood disorders. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 02/04/20 alle ore 02:54:09