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Titolo:
Increased cerebrospinal fluid glutamine levels in depressed patients
Autore:
Levine, J; Panchalingam, K; Rapoport, A; Gershon, S; McClure, RJ; Pettegrew, JW;
Indirizzi:
Univ Pittsburgh, Sch Med, Neurophys Lab, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA Ben Gurion Univ Negev, Fac Hlth Sci, Beersheva Mental Hlth Ctr, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel al Hlth Ctr, Beer Sheva, Israel Volfson Hosp, Dept Neurol, Holon, Israel Volfson Hosp Holon IsraelVolfson Hosp, Dept Neurol, Holon, Israel
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 47, anno: 2000,
pagine: 586 - 593
SICI:
0006-3223(20000401)47:7<586:ICFGLI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ENERGY-METABOLISM; EXCITATORY AMINO-ACIDS; NMDA RECEPTOR COMPLEX; MAJOR DEPRESSION; GLIAL-CELLS; CSF; SCHIZOPHRENIA; CHOLESTEROL; DISORDERS; PLASMA;
Keywords:
major depression; H-1 MRS; glutamine; creatine; beta-hydroxybutyrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Pettegrew, JW Univ Pittsburgh, Grad Sch Publ Hlth, Neurol & Hlth Serv Adm,A741 CrabtreeHall,130 De Soto St, Pittsburgh, PA 15213 USA Univ PittsburghA741 Crabtree Hall,130 De Soto St Pittsburgh PA USA 15213
Citazione:
J. Levine et al., "Increased cerebrospinal fluid glutamine levels in depressed patients", BIOL PSYCHI, 47(7), 2000, pp. 586-593

Abstract

Background: There is increasing evidence far an association between alterations of brain glutamatergic neuro-transmission? and the pathophysiology ofaffective disorders. Methods: We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versus control subjects using a proton magnetic resonance spectroscopy technique. Cerebrospinal fluid samples were obtained from 18 hospitalized patients with acute unmedicated severe depression without medical problems and compared with those of 22 control subjects. Results: Compared with the control group, the depressed patient group had significantly higher CSF glutamine concentrations, which correlated positively with CSF magnesium levels. Conclusions: These findings suggest art abnormality of the brain glial-neuronal glutamine/glutamate cycle associated with N-methyl-D-aspartate receptor systems in patients with depression. (C) 2000 Society of Biological Psychiatry.

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Documento generato il 27/01/20 alle ore 13:58:56