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Titolo:
Functional role of rat prelimbic-infralimbic cortices in spatial memory: evidence for their involvement in attention and behavioural flexibility
Autore:
Delatour, B; Gisquet-Verrier, P;
Indirizzi:
Univ Paris Sud, CNRS UMR 8620, Lab Neurobiol Apprentissage Memorie Commun,F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 Memorie Commun,F-91405 Orsay, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 109, anno: 2000,
pagine: 113 - 128
SICI:
0166-4328(200004)109:1<113:FRORPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; MORRIS WATER MAZE; FRONTAL-CORTEX; WORKING-MEMORY; DELAYED ALTERNATION; ANTERIOR CINGULATE; PARIETAL CORTEX; DOUBLE DISSOCIATION; LESIONS; HIPPOCAMPAL;
Keywords:
prefrontal cortex; planning of response; prospective memory; working memory; delayed non-matching to position task;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Gisquet-Verrier, P Univ Paris Sud, CNRS UMR 8620, Lab Neurobiol Apprentissage Memorie Commun,Bat 446, F-91405 Orsay, France Univ Paris Sud Bat 446 Orsay France F-91405 ay, France
Citazione:
B. Delatour e P. Gisquet-Verrier, "Functional role of rat prelimbic-infralimbic cortices in spatial memory: evidence for their involvement in attention and behavioural flexibility", BEH BRA RES, 109(1), 2000, pp. 113-128

Abstract

The involvement of the medial prefrontal cortex (mPFC), and more particularly the prelimbic and infralimbic cortices (PL-IL area), in spatial memory remains controversial. The present study investigates the effects of neurotoxic lesions restricted to the PL-IL area of the mPFC in rats trained in two different spatial tasks. In experiment I: PL-IL lesioned rats showed normal acquisition of a delayed non-matching to position task. They were also able to plan their responses for a prospective strategy but were transientlydisrupted when the initial delay was extended. In experiment 2, rats were trained to locate one baited box among 13 identical boxes distributed on a circular arena. Lesioned rats performed normally when trained from a singlestart position but were severely disrupted when four start positions were used. A probe trial showed this deficit was not due to failure to learn thegoal location. The addition of a proximal cue signalling the goal box helped lesioned rats to directly open the goal box, but did not compensate for greater distances that they travelled to reach it. Results from both experiments indicate that the PL-IL area is directly involved neither in allocentric spatial representations nor prospective,memory and is not specifically involved in working memory. This area seems more likely to be involved in both attentional processes and behavioural flexibility that may be importantfor processing information for working memory as well as for spatial memory. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/08/20 alle ore 08:42:49