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Titolo:
The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task
Autore:
Druzin, MY; Kurzina, NP; Malinina, EP; Kozlov, AP;
Indirizzi:
Inst Expt Med, Pavlov Physiol Dept, St Petersburg 197376, Russia Inst ExptMed St Petersburg Russia 197376 , St Petersburg 197376, Russia St Petersburg State Univ, Ukhtomsky Physiol Inst, Dept Psychophysiol, St Petersburg 199034, Russia St Petersburg State Univ St Petersburg Russia 199034 burg 199034, Russia
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 109, anno: 2000,
pagine: 99 - 111
SICI:
0166-4328(200004)109:1<99:TEOLAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY PERFORMANCE; SHORT-TERM-MEMORY; 6-HYDROXYDOPAMINE LESIONS; RECEPTOR MECHANISMS; POSITION TASK; UNIT-ACTIVITY; DORSAL PART; MONKEYS; NEURONS; RELEASE;
Keywords:
delayed spatial choice; medial prefrontal cortex; working memory; proactive interference; dopamine D2 receptor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kozlov, AP Umea Univ, Dept Integrat Med Biol, Physiol Sect, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 siol Sect, S-90187 Umea, Sweden
Citazione:
M.Y. Druzin et al., "The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task", BEH BRA RES, 109(1), 2000, pp. 99-111

Abstract

The study examined the effects of modulation of dopamine D2 receptors-mediated neurotransmission in the rat's prefrontal cortex (PFC) on storage and executive components of working memory. Rats were trained on delayed (delayinterval, 3 s) and non-delayed choice in a U-maze. The prominence of proactive interference was evaluated by sorting errors in a current trial on thebasis of animal reactions in a preceding trial. The erroneous runs to the same arm of the maze as in the previous trial were identified as the repetitions (RE) and the erroneous runs to the other arm in comparison with the previous trial were classified as alternations (AE). The bilateral microinfusion of D2 agonists PPHT (0.004 mu g, 0.04 mu g, 0.4 mu g/l mu l) into medial wall of the PFC produced a dose-dependent increase in the error rate of the delayed-response task and did not influence non-delayed choice. In delay condition PPHT enhanced the perseverative tendencies (the rate of RE was significantly higher than the rate of AE), in non-delayed choice the erroneous performance was mainly represented by AE. In contrast, the infusion of D2-receptor antagonist sulpiride (0.03 mu g, 0.3 mu g, 3 mu g/l mu l) increased the accuracy of delayed choice and changed the mode of intertrial dependence-rats made significantly more AE than RE. The results are discussed in terms of the involvement of D2 receptor dependent transmission of the PFCin different cognitive processes related to the delayed performance in U-maze (within-trial short-term storage of information versus dynamic control of between-trials working memory processing). (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.

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Documento generato il 22/01/20 alle ore 12:50:44