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Titolo:
Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation
Autore:
Murakami, Y; Ikenoya, M; Matsumoto, K; Li, HB; Watanabe, H;
Indirizzi:
Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Pharmacol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 109, anno: 2000,
pagine: 83 - 90
SICI:
0166-4328(200004)109:1<83:AEOTOS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC CEREBRAL HYPOPERFUSION; RADIAL MAZE PERFORMANCE; COMMON CAROTID ARTERIES; PERMANENT OCCLUSION; SENILE DEMENTIA; BLOOD-FLOW; CHOLINERGIC DYSFUNCTION; VASCULAR DEMENTIA; WORKING-MEMORY; ALZHEIMER-TYPE;
Keywords:
tacrine; radial maze; reversible effect; permanent occlusion of bilateral common carotid arteries; muscarinic M1 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, Y Toyama Med & Pharmaceut Univ, Inst Nat Med, Dept Pharmacol, 2630 Sugitani,Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
Y. Murakami et al., "Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation", BEH BRA RES, 109(1), 2000, pp. 83-90

Abstract

Our previous study demonstrated that permanent two-vessel occlusion (2VO)-induced working memory deficit was improved by daily administration of tacrine, a cholinesterase inhibitor. In this study, we investigated the mechanism underlying the effects of tacrine in 2VO rats using the eight-arm radialmaze task. Daily administration of tacrine (0.1 or 0.3 mg/kg i.p.) started5 weeks after the 2VO operation significantly improved the maze performance. In the delay-interposition task, a significant impairment of maze performance was observed in the tacrine (0.3 mg/kg, i.p.)-treated rats at a delayof 90 min but not delays of 5 or 30 min. Sham-operated rats were not affected by delay. After leaving animals with no,further treatment for 4 weeks, the tacrine-pretreated 2VO rats showed significantly impaired performance compared to the sham-operated control animals. However, the performance of the tacrine-pretreated 2VO rats was significantly improved by restarting thedaily administration of tacrine (0.3 mg/kg, i.p.). The effect of tacrine was reversed by the muscarinic antagonist scopolamine and the selective M1 antagonist pirenzepine. Moreover, a microdialysis study revealed that tacrine (1 or 3 mg/kg, i.p.) increased the extracellular acetylcholine (ACh) level for a period of over 3 h in the cerebral cortex of 2VO rats. These findings suggest that the ameliorative effect of tacrine on the spatial memory deficit in 2VO rats is reversible and may be mediated by stimulating the muscarinic M1 receptor via elevation of the extracellular ACh level in the brain. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:59:50