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Titolo:
Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test
Autore:
Bull, E; Reavill, C; Hagan, JJ; Overend, P; Jones, DNC;
Indirizzi:
SmithKline Beecham Pharmaceut PLC, Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut PLC Harlow Essex England CM19 5AW , England SmithKline Beecham Pharmaceut PLC, Stat Sci, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut PLC Harlow Essex England CM19 5AW , England
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 109, anno: 2000,
pagine: 27 - 35
SICI:
0166-4328(200004)109:1<27:EOTSHR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-FIELD BEHAVIOR; ANIMAL-MODEL; DEFICIT/HYPERACTIVITY DISORDER; SUSTAINED ATTENTION; SHR; METHYLPHENIDATE; ANTIDEPRESSANTS; REACTIVITY; CHILDREN; STRAINS;
Keywords:
attention deficit hyperactivity disorder; spontaneously hypertensive rat; Wistar-Kyoto; Sprague-Dawley; differential reinforcement of low rates of responding; impulsivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, DNC SmithKline Beecham Pharmaceut PLC, Neurosci Res, New Frontiers Sci Pk,3rd Ave, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut PLC New Frontiers Sci Pk,3rd Ave Harlow Essex England CM19 5AW
Citazione:
E. Bull et al., "Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test", BEH BRA RES, 109(1), 2000, pp. 27-35

Abstract

The spontaneously hypertensive rat (SHR) has been proposed as an animal model of attention deficit hyperactivity disorder (ADHD). It is hyperactive in a variety of behavioural paradigms and has a sustained attention deficit. This study investigated whether the SHR would exhibit impaired acquisitionand performance of a differential low rate (DRL) schedule of reinforcementbecause of increased impulsivity, compared with the Wistar-Kyoto (WKY) rat, its normotensive progenitor. In addition, the performance of both strainswas compared with Sprague-Dawley (CD) rats. SHR rats were not impaired in the acquisition of this test compared with WKY or CD rats. Indeed, WKY ratstook significantly longer to acquire this task than either SHR or CD rats. The WKY rats performed poorly compared with the other strains in those parts of training that required high response rates (e.g. FR-1), but better where low rates of responding were required (e.g. DRL-30s and DRL-60s). The rank order of efficiency when performance was measured under DRL-60s was WRY> SHR > CD. However, the pattern of responding at DRL-60s suggested poor schedule control for the WKY rats. Therefore, the performance of SHR in the DRL test does not appear to represent a valid model of ADHD. Further, our findings with the WKY rat suggest that this strain is a poor behavioural control for the SHR. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:14:11